Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192595 | 0.91 | MAPK9 (0.36) | P4HTMNPC1RAB9APTGS1PTGS2 | |
| SCHEMBL4203404 | 0.88 | PTGS1 (0.36) | NPC1RAB9APTGS1PTGS2MAPK9 | |
| SCHEMBL4197270 | 0.87 | PTGS1 (0.36) | NPC1RAB9APTGS1PTGS2MAPK9 | |
| SCHEMBL4190547 | 0.87 | MAPK9 (0.39) | NPC1RAB9APTGS1PTGS2MAPK9 | |
| SCHEMBL7707665 | 0.85 | NAAA (0.39) | NAAANPC1RAB9APTGS1PTGS2 | |
| SCHEMBL7707025 | 0.85 | NAAA (0.32) | NAAARAB9AMAPTLMNA | |
| SCHEMBL5613944 | 0.84 | MAPK8 (0.38) | P4HTMNPC1RAB9AMAPK9MAPK10 | |
| SCHEMBL7707443 | 0.84 | RAB9A (0.44) | NPC1RAB9APTGS1PTGS2MAPK9 | |
| SCHEMBL5613992 | 0.83 | PTGS1 (0.36) | NPC1RAB9APTGS1PTGS2MAPK9 | |
| SCHEMBL4197491 | 0.82 | CYP2D6 (0.38) | NPC1RAB9APTGS1PTGS2MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |