Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27854932 | 0.95 | LMNA (0.45) | LMNAKMT2AFGFR1FGFR4ADORA2A | |
| SCHEMBL29141665 | 0.89 | ADORA2A (0.41) | LMNAFGFR1FGFR4ADORA2ACYP1A2 | |
| SCHEMBL28704048 | 0.85 | TK1 (0.43) | FGFR1FGFR4ADORA2AALDH1A1CTSL | |
| SCHEMBL27887450 | 0.83 | FGFR1 (0.38) | FGFR1FGFR4HDAC1HDAC2ALDH1A1 | |
| SCHEMBL5839419 | 0.82 | FGFR1 (0.40) | FGFR1FGFR4ADORA2ANPC1ALDH1A1 | |
| SCHEMBL26605342 | 0.81 | ALDH1A1 (0.51) | LMNAKMT2AADORA2ATLR8GAA | |
| SCHEMBL15879501 | 0.81 | ALDH1A1 (0.51) | LMNAKMT2AADORA2ATLR8GAA | |
| SCHEMBL28232173 | 0.80 | FGFR1 (0.39) | FGFR1FGFR4ALDH1A1KDM4EHPGD | |
| SCHEMBL29942323 | 0.77 | LMNA (0.45) | LMNAKMT2AADORA2ATSHRCYP1A2 | |
| SCHEMBL4187055 | 0.76 | GLO1 (0.41) | LMNAKMT2ATSHRTLR8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |