Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | CCR5 | P51681 | 3/20 | 0.36 |
| ▸ | CCR8 | P51685 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5006801 | 0.80 | P2RX7 (0.45) | TSHRKDM4EMAPTCCR1CCR5 | |
| SCHEMBL4210015 | 0.78 | TRPV1 (0.40) | TRPV1TSHRKDM4EMAPTCCR1 | |
| Hydrochloric Acid SCHEMBL5003672 | 0.77 | MAPK1 (0.38) | TSHRKDM4EMAPTCCR1CCR5 | |
| Hydrochloric Acid SCHEMBL1072414 | 0.74 | CCR1 (0.46) | TSHRKDM4EMAPTCCR1CCR5 | |
| Hydrochloric Acid SCHEMBL5003132 | 0.74 | PDE4A (0.40) | MAPTHSP90AA1P2RX7 | |
| SCHEMBL3086250 | 0.73 | KDM4E (0.47) | TSHRKDM4EMAPTCCR1CCR5 | |
| Hydrochloric Acid SCHEMBL820330 | 0.72 | LMNA (0.40) | TSHRKDM4EMAPTCCR1CCR5 | |
| Hydrochloric Acid SCHEMBL819634 | 0.71 | CCR1 (0.40) | TSHRKDM4EMAPTCCR1CCR5 | |
| SCHEMBL2084240 | 0.70 | TRPV1 (0.50) | TRPV1TSHRKDM4EMAPTCCR1 | |
| Hydrochloric Acid SCHEMBL819935 | 0.69 | CCR1 (0.37) | TSHRKDM4EMAPTCCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544826-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2009-06-09 | — | — | US | disclosed |
| EP-1694689-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2009-03-11 | — | — | EP | disclosed |
| US-20070213484-A1 | Monocyclopentadienyl Complexes | BASELL POLYOLEFINE GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| EP-1694689-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058928-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213484-A1 | Monocyclopentadienyl Complexes | PCBP1, COASY, PORCN | CHRM1 2934/4885TRPV1 2713/4885TSHR 4849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.