Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | CCR1 | P32246 | 4/20 | 0.40 |
| ▸ | CCR8 | P51685 | 4/20 | 0.40 |
| ▸ | CCR5 | P51681 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL819935 | 0.88 | CCR1 (0.37) | LMNACCR1CCR8CCR5MMP2 | |
| Hydrochloric Acid SCHEMBL819634 | 0.85 | CCR1 (0.40) | LMNACCR1CCR8CCR5MMP2 | |
| Hydrochloric Acid SCHEMBL1685890 | 0.85 | TOP1 (0.43) | LMNAMAPTHSP90AA1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5006801 | 0.79 | P2RX7 (0.45) | LMNACCR1CCR8CCR5MMP2 | |
| Hydrochloric Acid SCHEMBL1072414 | 0.79 | CCR1 (0.46) | LMNACCR1CCR8CCR5MMP2 | |
| SCHEMBL3086250 | 0.77 | KDM4E (0.47) | LMNACCR1CCR8CCR5MMP2 | |
| SCHEMBL2875750 | 0.76 | CCR1 (0.40) | LMNACCR1CCR8CCR5MMP2 | |
| SCHEMBL27739271 | 0.75 | CCR1 (0.38) | LMNACCR1CCR8CCR5MMP2 | |
| Hydrochloric Acid SCHEMBL820651 | 0.74 | LMNA (0.41) | LMNACCR1CCR8CCR5MMP2 | |
| SCHEMBL4148271 | 0.74 | MMP2 (0.60) | LMNACCR1CCR8CCR5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943281-B1 | HYBRID CATALYST SYSTEMS SUPPORTED ON MAGNESIUM HALIDE | BASELL POLYOLEFINE GMBH (DE) | 2017-09-20 | — | — | EP | disclosed |
| EP-1740626-B1 | CATALYST SYSTEM FOR OLEFIN POLYMERIZATION, ITS PRODUCTION AND USE | BASELL POLYOLEFINE GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| US-8563674-B2 | Polyethylene and catalyst composition for its preparation | BASELL POLYOLEFINE GMBH (DE) | 2013-10-22 | — | — | US | disclosed |
| US-20120010377-A1 | Catalyst System for the Polymerization of Alpha-Olefins | BASELL POLYOLEFINE GMBH (DE) | 2012-01-12 | — | — | US | disclosed |
| US-7928051-B2 | Polyethylene for injection moldings | BASELL POLYOLEFINE GMBH (DE) | 2011-04-19 | — | — | US | disclosed |
| US-7868108-B2 | Transition metal compound, ligand system, catalyst system and process for preparing polyolefins | BASELL POLYOLEFINE GMBH (DE) | 2011-01-11 | — | — | US | disclosed |
| US-20100311925-A1 | Polyethylene and catalyst composition for its preparation | BASELL POLYOLEFINE GMBH (DE) | 2010-12-09 | — | — | US | disclosed |
| US-7767613-B2 | Polyethylene and catalyst composition for its preparation | BASELL POLYOLEFINE GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| US-7723448-B2 | Hybrid catalyst systems supported on magnesium halide | BASELL POLYOLEFINE GMBH (DE) | 2010-05-25 | — | — | US | disclosed |
| EP-1753791-B1 | POLYETHYLENE FOR INJECTION MOLDINGS | BASELL POLYOLEFINE GMBH (DE) | 2010-04-14 | — | — | EP | disclosed |
| EP-1753794-B8 | POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION | BASELL POLYOLEFINE GMBH (DE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1753794-B1 | POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION | BASELL POLYOLEFINE GMBH (DE) | 2008-06-04 | — | — | EP | disclosed |
| US-20070255033-A1 | Polyethylene for Injection Moldings | BASELL POYOLEFINE GMBH (DE) | 2007-11-01 | — | — | US | disclosed |
| US-20070213484-A1 | Monocyclopentadienyl Complexes | BASELL POLYOLEFINE GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213205-A1 | Polyethylene and Catalyst Composition for its Preparation | BASELL POLYOLEFINE GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070207916-A1 | Mixing organic transition metal compounds, hydrolyzed organoaluminum compound, and solvent, then impregnating dry porous support | BASELL POLYOLEFINE GMBH (DE) | 2007-09-06 | — | — | US | disclosed |
| EP-1753794-A1 | POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION | Basell Polyolefine GmbH (DE) | 2007-02-21 | — | — | EP | disclosed |
| EP-1694689-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005103100-A1 | POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION | BASELL POLYOLEFINE GMBH (DE) | 2005-11-03 | — | — | WO | disclosed |
| WO-2005058928-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213484-A1 | Monocyclopentadienyl Complexes | PCBP1, COASY, PORCN | CHRM1 2934/4885LMNA 2688/4885CCR1 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.