Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 3/20 | 0.37 |
| ▸ | CCR8 | P51685 | 3/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5006801 | 0.84 | P2RX7 (0.45) | LMNACYP2D6MAPTADRA1ACCR1 | |
| Hydrochloric Acid SCHEMBL819634 | 0.80 | CCR1 (0.40) | LMNACYP2D6MAPTADRA1ACCR1 | |
| Hydrochloric Acid SCHEMBL4195070 | 0.77 | TRPV1 (0.38) | LMNACYP2D6MAPTADRA1ACCR1 | |
| Hydrochloric Acid SCHEMBL5009094 | 0.76 | MAPT (0.38) | MAPK1ADRA2AADRA2BADRA2CTAAR1 | |
| Hydrochloric Acid SCHEMBL5003132 | 0.76 | PDE4A (0.40) | MAPTP2RX7HSP90AA1 | |
| SCHEMBL27739271 | 0.76 | CCR1 (0.38) | LMNACYP2D6MAPTNISCHCCR1 | |
| Phenanthroline SCHEMBL17870543 | 0.74 | LMNA (0.55) | MAPK1ADRA2AADRA2BADRA2CTAAR1 | |
| Hydrochloric Acid SCHEMBL1072414 | 0.74 | CCR1 (0.46) | LMNACYP2D6MAPTADRA1ACCR1 | |
| Hydrochloric Acid SCHEMBL820330 | 0.74 | LMNA (0.40) | LMNACYP2D6MAPTADRA1ACCR1 | |
| SCHEMBL3086250 | 0.72 | KDM4E (0.47) | MAPK1LMNACYP2D6MAPTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269445-A1 | Monocyclopentadienyl Complexes | BASELL POLYOLEFINE GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269445-A1 | Monocyclopentadienyl Complexes | PCBP1, COASY, PORCN | MAPK1 3474/4885ADRA2A 4537/4885ADRA2B 4641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.