Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825722 | 0.93 | LMNA (0.40) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL7710188 | 0.92 | LMNA (0.40) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL4197137 | 0.91 | MEN1 (0.41) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL7701881 | 0.89 | ATP4A (0.41) | KMT2AALDH1A1GAA | |
| SCHEMBL7707443 | 0.89 | RAB9A (0.44) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL4203402 | 0.87 | RAB9A (0.43) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL5613949 | 0.84 | PDE10A (0.36) | LMNAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4186370 | 0.81 | RAB9A (0.42) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL4190547 | 0.80 | MAPK9 (0.39) | LMNAMAPTMEN1KMT2ARAB9A | |
| SCHEMBL5613965 | 0.80 | ATP4A (0.35) | LMNAMAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |
| WO-2006104983-A1 | THERAPEUTIC METHODS FOR TYPE I DIABETES | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL (US) | 2006-10-05 | — | — | WO | disclosed |
| EP-1696909-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | Applied Research Systems ARS Holding N.V. (AN) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005025567-A1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | disclosed |