Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707443 | 0.91 | RAB9A (0.44) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL4201459 | 0.87 | LMNA (0.45) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL4197137 | 0.86 | MEN1 (0.41) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL7710188 | 0.86 | LMNA (0.40) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL6825722 | 0.85 | LMNA (0.40) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL5613944 | 0.84 | MAPK8 (0.38) | RAB9AMEN1KMT2ALMNAHTT | |
| SCHEMBL4186370 | 0.84 | RAB9A (0.42) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL5613884 | 0.83 | HTR1A (0.35) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL5613965 | 0.83 | ATP4A (0.35) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL5613855 | 0.82 | ALDH1A1 (0.37) | RAB9ALMNASMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |