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SCHEMBL4201570

SCHEMBL4201570

CC(C)(C)c1cc(N)n(-c2ccc(O[Si](C)(C)C(C)(C)C)c(Cl)c2)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.40
▸ KMT2A Q03164 6/20 0.40
▸ NPC1 O15118 3/20 0.37
▸ RAB9A P51151 3/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ RECQL P46063 1/20 0.37
▸ PRKCZ Q05513 1/20 0.36
▸ RIPK2 O43353 1/20 0.35
▸ MAPK14 Q16539 3/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ ABL2 P42684 1/20 0.34
▸ MAPK8 P45983 1/20 0.34
▸ MAPK11 Q15759 1/20 0.34
▸ TRPV1 Q8NER1 2/20 0.33
▸ SRC P12931 1/20 0.33
▸ DDR2 Q16832 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ APEX1 P27695 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4200295 0.90 RIPK2 (0.42) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL14688275 0.85 MEN1 (0.52) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL981523 0.84 MEN1 (0.39) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL4081884 0.84 MEN1 (0.42) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL1284129 0.81 LMNA (0.44) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL13946380 0.80 L3MBTL1 (0.49) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL16866574 0.80 MEN1 (0.34) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL28708329 0.79 TP53 (0.46) MEN1KMT2ANPC1RAB9AL3MBTL1
SCHEMBL16279956 0.79 MAPK14 (0.35) PRKCZMAPK14ABL1ABL2MAPK8
SCHEMBL4070541 0.79 ALDH1A1 (0.40) MEN1KMT2ANPC1RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US disclosed
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US disclosed
US-20090012079-A1 Triazolopyridine Compounds LEWTHWAITE RUSSELL ANDREW 2009-01-08 — — US disclosed
US-20090012079-A1 Triazolopyridine Compounds LEWTHWAITE RUSSELL ANDREW 2009-01-08 — — US disclosed
EP-1987022-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES Pfizer Products Inc. (US) 2008-11-05 — — EP disclosed
EP-1984363-A1 TRIAZOLOPYRIDINE COMPOUNDS Pfizer Limited (GB) 2008-10-29 — — EP disclosed
WO-2007091176-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-08-16 — — WO disclosed
WO-2007091152-A1 TRIAZOLOPYRIDINE COMPOUNDS PFIZER LIMITED (GB) 2007-08-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012079-A1 Triazolopyridine Compounds MAPKAPK5, MAPK1, MAPK4 MEN1 4823/4885KMT2A 4216/4885NPC1 1091/4885
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PDXK, UMPS, CDK2 MEN1 4558/4885KMT2A 2604/4885NPC1 4791/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.