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SCHEMBL4200295

SCHEMBL4200295

CC(C)(C)c1cc(N)n(-c2ccc(Cl)c(O[Si](C)(C)C(C)(C)C)c2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RIPK2 O43353 1/20 0.42
▸ MAPT P10636 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ RECQL P46063 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ PRKCZ Q05513 1/20 0.36
▸ MAPK14 Q16539 7/20 0.34
▸ MAPK11 Q15759 2/20 0.34
▸ ABL1 P00519 1/20 0.34
▸ ABL2 P42684 1/20 0.34
▸ MAPK8 P45983 1/20 0.34
▸ SRC P12931 1/20 0.33
▸ DDR2 Q16832 1/20 0.33
▸ CDK8 P49336 1/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ CYP1A2 P05177 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ CYP2C9 P11712 2/20 0.33
▸ CYP2C19 P33261 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4201570 0.90 MEN1 (0.40) RIPK2MAPTMAPK1RECQLL3MBTL1
SCHEMBL4081884 0.86 MEN1 (0.42) MAPTMAPK1L3MBTL1MAPK14MAPK11
SCHEMBL14434706 0.81 RIPK2 (0.42) RIPK2MAPTMAPK1RECQLL3MBTL1
SCHEMBL1284129 0.81 LMNA (0.44) MAPTMAPK1RECQLL3MBTL1MAPK14
SCHEMBL13946380 0.80 L3MBTL1 (0.49) RIPK2MAPTMAPK1RECQLL3MBTL1
SCHEMBL16279956 0.79 MAPK14 (0.35) PRKCZMAPK14MAPK11ABL1ABL2
SCHEMBL4070541 0.79 ALDH1A1 (0.40) RIPK2MAPTMAPK1RECQLL3MBTL1
SCHEMBL14688275 0.77 MEN1 (0.52) RIPK2MAPTMAPK1RECQLL3MBTL1
SCHEMBL4199674 0.77 PRKCZ (0.48) RIPK2MAPTMAPK1RECQLL3MBTL1
SCHEMBL28708329 0.77 TP53 (0.46) MAPTMAPK1RECQLL3MBTL1PRKCZ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US disclosed
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PFIZER INC. 2009-10-29 — — US disclosed
US-20090012079-A1 Triazolopyridine Compounds LEWTHWAITE RUSSELL ANDREW 2009-01-08 — — US disclosed
US-20090012079-A1 Triazolopyridine Compounds LEWTHWAITE RUSSELL ANDREW 2009-01-08 — — US disclosed
EP-1987022-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES Pfizer Products Inc. (US) 2008-11-05 — — EP disclosed
WO-2007091176-A1 PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-08-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012079-A1 Triazolopyridine Compounds MAPKAPK5, MAPK1, MAPK4 RIPK2 715/4885MAPT 851/4885MAPK1 2/4885
US-20090270350-A1 Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives PDXK, UMPS, CDK2 RIPK2 646/4885MAPT 2264/4885MAPK1 11/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.