Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.69 |
| ▸ | MAOA | P21397 | 8/20 | 0.69 |
| ▸ | CES1 | P23141 | 6/20 | 0.51 |
| ▸ | TGM2 | P21980 | 5/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377143 | 0.86 | TGM2 (0.69) | MAOBMAOACES1TGM2CNR1 | |
| SCHEMBL5327486 | 0.86 | MAOA (0.63) | MAOBMAOACES1TGM2BCHE | |
| SCHEMBL19642904 | 0.79 | MAOB (0.63) | MAOBMAOACES1TGM2BCHE | |
| SCHEMBL13375281 | 0.79 | MAOA (0.63) | MAOBMAOACES1TGM2BCHE | |
| SCHEMBL13594800 | 0.78 | MAOA (0.58) | MAOBMAOACES1TGM2BCHE | |
| SCHEMBL12470147 | 0.78 | MAOA (0.58) | MAOBMAOACES1TGM2BCHE | |
| SCHEMBL3742475 | 0.77 | MAOB (0.70) | MAOBMAOACES1TGM2ALDH1A1 | |
| SCHEMBL11052024 | 0.77 | CNR1 (0.50) | MAOBMAOACNR1CNR2ALDH1A1 | |
| SCHEMBL5133044 | 0.76 | MAOB (0.73) | MAOBMAOACES1TGM2ALDH1A1 | |
| SCHEMBL9727978 | 0.75 | MAOA (0.77) | MAOBMAOACES1TGM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032584-A2 | THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | Wyeth (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | WYETH (US) | 2008-05-29 | — | — | US | disclosed |
| WO-2007146138-A2 | THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125469-A1 | Thiadiazole compounds and methods of use thereof | ADAMTS5, ADAMTS1, TIMP3 | MAOB 1987/4885MAOA 2263/4885CES1 1357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.