Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193079 | 0.87 | PNP (0.52) | PNPTLR7ADORA3MEN1KMT2A | |
| SCHEMBL5641835 | 0.79 | PNP (0.60) | PNPTLR7ADORA3MEN1KMT2A | |
| SCHEMBL4624542 | 0.77 | PNP (0.60) | PNPTLR7ADORA3MEN1KMT2A | |
| SCHEMBL18113975 | 0.76 | PNP (0.56) | PNPTLR7ADORA3MEN1KMT2A | |
| SCHEMBL10958065 | 0.74 | P2RX7 (0.49) | PNPADORA3MEN1KMT2AHTT | |
| SCHEMBL22560010 | 0.74 | PNP (0.65) | PNPTLR7HPGDADORA2A | |
| SCHEMBL21389547 | 0.72 | TLR7 (0.51) | PNPTLR7MEN1KMT2AHPGD | |
| SCHEMBL10826355 | 0.71 | ALDH1A1 (0.48) | PNPMEN1KMT2ATSHRHTT | |
| SCHEMBL3115741 | 0.71 | ADORA2A (0.58) | PNPMEN1KMT2AKDM4EHPGD | |
| SCHEMBL8355232 | 0.71 | ADORA3 (0.65) | PNPTLR7ADORA3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845993-A4 | NOVEL ADENOSINE A3 RECEPTOR MODULATORS | KING PHARMACEUTICALS RES & DEV (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1845993-A2 | NOVEL ADENOSINE A3 RECEPTOR MODULATORS | King Pharmaceuticals Research and Development Inc. (US) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006083916-A2 | NOVEL ADENOSINE A3 RECEPTOR MODULATORS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2006-08-10 | — | — | WO | disclosed |