Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.48 |
| ▸ | ACLY | P53396 | 9/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4204509 | 0.94 | ACLY (0.43) | GHSRACLYHTR6QRFPRKEAP1 | |
| SCHEMBL4201831 | 0.92 | ACLY (0.46) | GHSRACLYHTR6QRFPRKEAP1 | |
| SCHEMBL4209213 | 0.91 | HTR6 (0.47) | HTR6QRFPRKEAP1NFE2L2HTR7 | |
| SCHEMBL4201660 | 0.89 | ALDH1A1 (0.46) | HTR6QRFPRKEAP1NFE2L2HTR7 | |
| SCHEMBL4204125 | 0.89 | KEAP1 (0.49) | GHSRHTR6QRFPRKEAP1NFE2L2 | |
| SCHEMBL4210799 | 0.88 | HTR6 (0.42) | HTR6QRFPRKEAP1NFE2L2HTR7 | |
| SCHEMBL4196123 | 0.88 | GHSR (0.47) | GHSRHTR6QRFPRKEAP1NFE2L2 | |
| SCHEMBL4967087 | 0.88 | GHSR (0.47) | GHSRHTR6QRFPRKEAP1NFE2L2 | |
| SCHEMBL4201079 | 0.88 | HTR6 (0.50) | ACLYHTR6QRFPRPTGES2HTR7 | |
| Acetic Acid SCHEMBL4208418 | 0.88 | HTR6 (0.44) | ACLYHTR6QRFPRHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | claimed |
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | disclosed |
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | HTR6, HTR1A, HTR1D | GHSR 283/4885ACLY 4002/4885HTR6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.