Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19121839 | 0.86 | PTGS1 (0.45) | PTGS1PTGS2MMP8ALDH1A1TP53 | |
| SCHEMBL3905021 | 0.85 | ADRB1 (0.45) | PTGS1PTGS2MMP8KDM4ETSHR | |
| SCHEMBL31074078 | 0.85 | ADRB1 (0.45) | PTGS1PTGS2MMP8KDM4ETSHR | |
| SCHEMBL29484096 | 0.84 | PTGS1 (0.62) | PTGS1PTGS2ALDH1A1ACP3AKR1C3 | |
| SCHEMBL1492817 | 0.84 | PTGS1 (0.62) | PTGS1PTGS2ALDH1A1ACP3AKR1C3 | |
| SCHEMBL1653533 | 0.84 | PTGS1 (0.62) | PTGS1PTGS2ALDH1A1ACP3AKR1C3 | |
| SCHEMBL1491141 | 0.84 | MMP8 (0.53) | MMP8ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL11189555 | 0.83 | ALDH1A1 (0.46) | PTGS1PTGS2MMP8ALDH1A1KDM4E | |
| SCHEMBL16322386 | 0.83 | PSEN1 (0.49) | PTGS1PTGS2MMP8ALDH1A1TP53 | |
| SCHEMBL11100405 | 0.83 | PTGS1 (0.43) | PTGS1PTGS2MMP8ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021123848-A1 | PROCESS FOR THE PREPARATION OF A CHIRAL PROSTAGLANDIN ENOL INTERMEDIATE AND INTERMEDIATE COMPOUNDS USEFUL IN THE PROCESS | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) | 2021-06-24 | — | — | WO | disclosed |
| CN-102414207-B | Fluorinated aminotriazole derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2015-09-30 | — | — | CN | disclosed |
| US-20120178743-A1 | NOVEL ADENINE COMPOUND AND USE THEREOF | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-12 | — | — | US | disclosed |
| US-20120178743-A1 | NOVEL ADENINE COMPOUND AND USE THEREOF | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-12 | — | — | US | disclosed |
| EP-1550662-B1 | ADENINE COMPOUND AND USE THEREOF | DAINIPPON SUMITOMO PHARMA CO (JP) | 2012-07-04 | — | — | EP | disclosed |
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | FINSINGER DIRK (DE) | 2012-05-24 | — | — | US | disclosed |
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | FINSINGER DIRK (DE) | 2012-05-24 | — | — | US | disclosed |
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | FINSINGER DIRK (DE) | 2012-05-24 | — | — | US | disclosed |
| US-20090118267-A1 | INDANES | MERCK PATENT GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| US-20090118267-A1 | INDANES | MERCK PATENT GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| US-20090118267-A1 | INDANES | MERCK PATENT GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| US-20080275044-A1 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2008-11-06 | — | — | US | disclosed |
| US-5220060-A | Reacting ester with carbon monoxide in liquid phase with catalyst system of palladium compound, iodide promoter, proton donor | CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| US-5008451-A | Producing carboxylic anhydrides by reacting a carboxylic ester with carbon monoxide using a phodium catalyst, iodide promoter, proton donor and anhydrous conditions | CHEVRON RESEARCH COMPANY (US) | 1991-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130147-A1 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS | TP53, IDH3A, IDH2 | PTGS1 407/4885PTGS2 369/4885MMP8 2316/4885 |
| US-20090118267-A1 | INDANES | IDH3A, CYP1A1, CCNT1 | PTGS1 319/4885PTGS2 609/4885MMP8 4232/4885 |
| US-20080275044-A1 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them and use thereof for treating pain and other conditions | TRPV1, TRPV2, TRPV3 | PTGS1 135/4885PTGS2 189/4885MMP8 1132/4885 |
| US-20120178743-A1 | NOVEL ADENINE COMPOUND AND USE THEREOF | ADORA1, HRH4, P2RY10 | PTGS1 946/4885PTGS2 1300/4885MMP8 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.