Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12707192 | 0.87 | KMT2A (0.48) | MMP8ALDH1A1ACP3 | |
| SCHEMBL2511176 | 0.86 | MMP8 (0.44) | MMP8ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL9136495 | 0.84 | MMP8 (0.44) | MMP8ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL4210524 | 0.84 | PTGS1 (0.45) | MMP8ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL290364 | 0.83 | MMP8 (0.54) | MMP8ALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL20346320 | 0.83 | MMP8 (0.50) | MMP8ALDH1A1TDP1L3MBTL1CA12 | |
| SCHEMBL9138377 | 0.83 | ALDH1A1 (0.43) | MMP8ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL29824513 | 0.83 | MMP8 (0.54) | MMP8ALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL6367101 | 0.83 | ALDH1A1 (0.43) | MMP8ALDH1A1TP53TDP1KDM4E | |
| SCHEMBL9052329 | 0.83 | MMP8 (0.50) | MMP8ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564208-B1 | METHOD FOR PREPARING 2-(CYCLOHEXENYLENE) MALONIC ACID DERIVATIVE AND USE THEREOF | ORIENTAL LUZHOU AGROCHEMICALS CO LTD (CN) | 2021-11-10 | — | — | EP | disclosed |
| CN-108264463-B | Method for preparing 2-aryl malonic acid derivative and application thereof | 浙江省诸暨合力化学对外贸易有限公司 | 2021-04-09 | — | — | CN | disclosed |
| US-10836777-B2 | Method for preparing 2-(cyclohexenylidene) malonic acid derivatives and uses thereof | ORIENTAL(LUZHOU) AGROCHEMICALS. CO., LTD (CN) | 2020-11-17 | — | — | US | disclosed |
| CN-108264469-B | Method for preparing 2- (cyclohexenylene) malonic acid derivative and application thereof | 泸州东方农化有限公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-107531700-B | Mesoionic compounds | 日本化药株式会社 | 2020-03-03 | — | — | CN | disclosed |
| EP-3564208-A1 | METHOD FOR PREPARING 2-(CYCLOHEXENYLENE) MALONIC ACID DERIVATIVE AND USE THEREOF | Oriental (Luzhou) Agrochemicals. Co., Ltd. (CN) | 2019-11-06 | — | — | EP | disclosed |
| US-20190292200-A1 | METHOD FOR PREPARING 2-(CYCLOHEXENYLIDENE) MALONIC ACID DERIVATIVES AND USES THEREOF | ORIENTAL(LUZHOU) AGROCHEMICALS. CO., LTD. (CN) | 2019-09-26 | — | — | US | disclosed |
| EP-3287457-B1 | MESOIONIC COMPOUND | NIPPON KAYAKU KK (JP) | 2019-09-18 | — | — | EP | disclosed |
| US-20180310564-A1 | Mesoionic Compound | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2018-11-01 | — | — | US | disclosed |
| EP-3287457-A1 | MESOIONIC COMPOUND | Nippon Kayaku Kabushiki Kaisha (JP) | 2018-02-28 | — | — | EP | disclosed |
| WO-2009143183-A1 | PYRIMIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009143180-A1 | PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION THE (US) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009143180-A1 | PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION THE (US) | 2009-11-26 | — | — | WO | disclosed |
| US-20090286818-A1 | Pyridine Non-Classical Cannabinoid Compounds and Related Methods of Use | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-11-19 | — | — | US | disclosed |
| US-20090286818-A1 | Pyridine Non-Classical Cannabinoid Compounds and Related Methods of Use | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-11-19 | — | — | US | disclosed |
| US-20090286818-A1 | Pyridine Non-Classical Cannabinoid Compounds and Related Methods of Use | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-11-19 | — | — | US | disclosed |
| US-20090286810-A1 | Pyrimidine Non-Classical Cannabinoid Compounds and Related Methods of Use | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-11-19 | — | — | US | disclosed |
| US-20090286810-A1 | Pyrimidine Non-Classical Cannabinoid Compounds and Related Methods of Use | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-11-19 | — | — | US | disclosed |
| CN-100432070-C | Novel sulfamides and their use as endothelin receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-12 | — | — | CN | disclosed |
| CN-1524079-A | Novel sulfonamides and their use as endothelin receptor antagonists | ������˹ҩƷ��˾ | 2004-08-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836777-B2 | Method for preparing 2-(cyclohexenylidene) malonic acid derivatives and uses thereof | ME1, HPD, PIN4 | MMP8 4355/4885ALDH1A1 565/4885TP53 3257/4885 |
| US-20090286810-A1 | Pyrimidine Non-Classical Cannabinoid Compounds and Related Methods of Use | CNR1, CNR2, GPR18 | MMP8 4769/4885ALDH1A1 2484/4885TP53 4089/4885 |
| US-20180310564-A1 | Mesoionic Compound | MTX1, METTL3, MTX2 | MMP8 1567/4885ALDH1A1 2646/4885TP53 4332/4885 |
| US-20190292200-A1 | METHOD FOR PREPARING 2-(CYCLOHEXENYLIDENE) MALONIC ACID DERIVATIVES AND USES THEREOF | ME1, HPD, PIN4 | MMP8 4355/4885ALDH1A1 565/4885TP53 3257/4885 |
| US-20090286818-A1 | Pyridine Non-Classical Cannabinoid Compounds and Related Methods of Use | CNR1, CNR2, NPY1R | MMP8 4565/4885ALDH1A1 3257/4885TP53 4606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.