SCHEMBL4215409

SCHEMBL4215409

[Li]c1ccc(O[Si](C)(C)C)c(CC=C)c1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 8/20 0.38
GABRB2 P47870 8/20 0.38
CNR2 P34972 4/20 0.38
ALOX5 P09917 4/20 0.38
ALDH1A1 P00352 2/20 0.37
PPARG P37231 1/20 0.37
PPARD Q03181 1/20 0.37
PPARA Q07869 1/20 0.37
ELANE P08246 1/20 0.36
PTGDR Q13258 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35
CYP3A4 P08684 2/20 0.35
ALOX15 P16050 1/20 0.35
CNR1 P21554 1/20 0.34
AR P10275 1/20 0.34
PTGS1 P23219 1/20 0.34
TRPM8 Q7Z2W7 1/20 0.34
PTPN1 P18031 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16393672 0.81 MAPT (0.40) GABRA1GABRB2CNR2ALOX5ALDH1A1
SCHEMBL4221328 0.81 MEN1 (0.43) GABRA1GABRB2CNR2ALOX5ALDH1A1
SCHEMBL16885495 0.78 ELANE (0.40) GABRA1GABRB2CNR2ALOX5ALDH1A1
SCHEMBL29609173 0.78 ELANE (0.40) GABRA1GABRB2CNR2ALOX5ALDH1A1
SCHEMBL16885522 0.77 POLB (0.55) GABRA1GABRB2CNR2ALOX5ALDH1A1
SCHEMBL8961940 0.76 ALDH1A1 (0.47) ALDH1A1
SCHEMBL29699897 0.76 ALDH1A1 (0.47) ALDH1A1
SCHEMBL16393687 0.75 ELANE (0.35) GABRA1GABRB2CNR2ALOX5ALDH1A1
SCHEMBL21277577 0.74 GABRA1 (0.45) GABRA1GABRB2CNR2ALOX5ALDH1A1
SCHEMBL23521372 0.72 ELANE (0.36) GABRA1GABRB2CNR2ALOX5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7557152-B2 Reactive flame retardant and flame-retardant resin processed article FUJI ELECTRIC HOLDINGS CO., LTD. (JP) 2009-07-07 US disclosed
US-20090043032-A1 REACTIVE FLAME RETARDANT AND FLAME-RETARDANT RESIN PROCESSED ARTICLE FUJI ELECTRIC HOLDINGS CO., LTD. (JP) 2009-02-12 US disclosed
EP-1852489-A1 REACTIVE FLAME RETARDANT AND FLAME-RETARDANT RESIN PROCESSED ARTICLE FUJI ELECTRIC HOLDINGS CO., LTD.; (JP) 2007-11-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090043032-A1 REACTIVE FLAME RETARDANT AND FLAME-RETARDANT RESIN PROCESSED ARTICLE F11, PF4, RXRA GABRA1 265/4885GABRB2 616/4885CNR2 4709/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.