Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8982103 | 0.91 | HTR7 (0.53) | ABCB1TMEM97HTR7SIGMAR1 | |
| SCHEMBL4222537 | 0.88 | ALDH1A1 (0.63) | ALDH1A1POLBHTR7SIGMAR1MEN1 | |
| Hydrochloric Acid SCHEMBL4228567 | 0.87 | SIGMAR1 (0.61) | POLBTMEM97HTR7SIGMAR1 | |
| SCHEMBL8981452 | 0.86 | HTR7 (0.58) | ABCB1TMEM97HTR7SIGMAR1 | |
| SCHEMBL8982250 | 0.86 | DRD4 (0.58) | ABCB1HTR7 | |
| SCHEMBL8982140 | 0.86 | SIGMAR1 (0.59) | ABCB1TMEM97HTR7SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4232329 | 0.86 | HTR7 (0.70) | ALDH1A1POLBHTR7MEN1KMT2A | |
| SCHEMBL8983429 | 0.86 | HTR7 (0.72) | ABCB1TMEM97HTR7SIGMAR1 | |
| SCHEMBL8982167 | 0.86 | HTR7 (0.59) | POLBABCB1TMEM97HTR7SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4228381 | 0.85 | HTR7 (0.55) | ALDH1A1HTR7SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
| US-20060040978-A1 | 5-HT7 receptor antagonists | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163542-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | ALDH1A1 2903/4885POLB 3629/4885ABCB1 528/4885 |
| US-20060040978-A1 | 5-HT7 receptor antagonists | HTR7, HTR1A, HTR5A | ALDH1A1 2903/4885POLB 3629/4885ABCB1 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.