SCHEMBL422880

SCHEMBL422880

O=C(NN=C(c1ccccc1O)c1ccccc1O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTA1 P08263 3/20 1.00
KDM1A O60341 2/20 0.59
NPC1 O15118 4/20 0.55
RAB9A P51151 4/20 0.55
KDM4E B2RXH2 4/20 0.55
CTDSP1 Q9GZU7 1/20 0.55
KMT2A Q03164 5/20 0.53
MEN1 O00255 4/20 0.53
ALDH1A1 P00352 1/20 0.53
GLA P06280 1/20 0.53
MAPT P10636 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
GAA P10253 4/20 0.53
AGTR1 P30556 1/20 0.53
MAPK1 P28482 1/20 0.53
POLB P06746 1/20 0.48
LMNA P02545 1/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1562888 0.86 GSTA1 (0.76) GSTA1KDM1ANPC1RAB9AKDM4E
SCHEMBL684658 0.83 KDM1A (0.83) GSTA1KDM1ANPC1RAB9AKDM4E
SCHEMBL1563675 0.81 GSTA1 (0.69) GSTA1NPC1RAB9AKDM4EKMT2A
SCHEMBL1562723 0.81 GSTA1 (0.68) GSTA1NPC1RAB9AKDM4EKMT2A
SCHEMBL685189 0.81 GSTA1 (0.68) GSTA1KDM1ANPC1RAB9AKDM4E
SCHEMBL685379 0.80 GSTA1 (0.66) GSTA1KDM1ANPC1RAB9AKDM4E
SCHEMBL1563550 0.80 GSTA1 (0.66) GSTA1KDM1ANPC1RAB9AKDM4E
SCHEMBL684933 0.80 GSTA1 (0.66) GSTA1KDM1ANPC1RAB9AKDM4E
SCHEMBL6635118 0.80 GSTA1 (0.66) GSTA1KDM1ANPC1RAB9AKDM4E
SCHEMBL19032011 0.78 NPC1 (0.70) GSTA1NPC1RAB9AKDM4ECTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8563472-B2 Synergistic fungicidal and algicidal compositions including 2-hydroxyphenylaldehyde and 2-hydroxyphenylketone heterocycloyhydrazones and copper DOW AGROSCIENCES, LLC. (US) 2013-10-22 US disclosed
US-8476194-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC (US) 2013-07-02 US disclosed
EP-2605651-A1 SYNERGISTIC FUNGICIDAL AND ALGICIDAL COMPOSITIONS INCLUDING 2-HYDROXYPHENYLALDEHYDE AND 2-HYDROXYPHENYLKETONE HETEROCYCLOYLHYDRAZONES AND COPPER Dow AgroSciences LLC (US) 2013-06-26 EP disclosed
EP-2605653-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER Dow AgroSciences LLC (US) 2013-06-26 EP disclosed
EP-2605660-A2 SYNERGISTIC FUNGICIDAL AND ALGICIDAL COMPOSITIONS INCLUDING 7-HYDROXY-INDANONE BENZOYLHYDRAZONES AND COPPER Dow AgroSciences LLC (US) 2013-06-26 EP disclosed
US-20120148682-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-06-14 US disclosed
US-20120141597-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-06-07 US disclosed
US-20120045522-A1 SYNERGISTIC FUNGICIDAL AND ALGICIDAL COMPOSITIONS INCLUDING 7-HYDROXY-INDANONE BENZOYLHYDRAZONES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120021066-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-26 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
EP-2376441-A2 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER Dow AgroSciences LLC (US) 2011-10-19 EP disclosed
EP-2376436-A2 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER Dow AgroSciences LLC (US) 2011-10-19 EP disclosed
EP-2376438-A2 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER Dow AgroSciences LLC (US) 2011-10-19 EP disclosed
EP-2376435-A2 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER Dow AgroSciences LLC (US) 2011-10-19 EP disclosed
WO-2010083307-A2 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2010-07-22 WO disclosed
WO-2010083319-A2 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2010-07-22 WO disclosed
WO-2010083310-A2 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2010-07-22 WO disclosed
WO-2010083316-A2 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2010-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 GSTA1 784/4885KDM1A 484/4885NPC1 1690/4885
US-20120045522-A1 SYNERGISTIC FUNGICIDAL AND ALGICIDAL COMPOSITIONS INCLUDING 7-HYDROXY-INDANONE BENZOYLHYDRAZONES AND COPPER ERG28, CYP3A7, UGT1A7 GSTA1 2348/4885KDM1A 2027/4885NPC1 1728/4885
US-20120021066-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 GSTA1 700/4885KDM1A 291/4885NPC1 1052/4885
US-20120148682-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 GSTA1 700/4885KDM1A 291/4885NPC1 1052/4885
US-20120141597-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 GSTA1 700/4885KDM1A 291/4885NPC1 1052/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.