Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 12/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL429396 | 1.00 | ALDH1A1 (0.50) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Citric Acid SCHEMBL10006614 | 0.98 | ALDH1A1 (0.52) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Citric Acid SCHEMBL425500 | 0.93 | ALDH1A1 (0.54) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Isostearyl Alcohol SCHEMBL27515351 | 0.88 | ALDH1A1 (0.52) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Citric Acid SCHEMBL28368098 | 0.88 | ALDH1A1 (0.52) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Citric Acid SCHEMBL28737256 | 0.88 | ALDH1A1 (0.52) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Citric Acid SCHEMBL425328 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Citric Acid SCHEMBL427082 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HSPD1BLMHSPE1ACLY | |
| Citric Acid SCHEMBL1550228 | 0.84 | ALDH1A1 (0.71) | ALDH1A1ACLYMAPTKDM4ELMNA | |
| Citric Acid SCHEMBL427796 | 0.84 | ALDH1A1 (0.71) | ALDH1A1ACLYMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | HENKEL AG & CO. KGAA (DE) | 2012-01-26 | — | — | US | claimed |
| US-20170157025-A1 | TEXTILE FRIENDLY ANTIPERSPIRANT COMPOSITIONS | HENKEL AG & CO. KGAA (DE) | 2017-06-08 | — | — | US | disclosed |
| US-8828367-B2 | Water-free antiperspirant non-aerosols in which active substances are more readily released | HENKEL AG & CO. KGAA (DE) | 2014-09-09 | — | — | US | disclosed |
| US-8603445-B2 | Water-free antiperspirant sprays in which active substances are more readily released | HENKEL AG & CO. KGAA (DE) | 2013-12-10 | — | — | US | disclosed |
| US-20120177589-A1 | WATER-FREE ANTIPERSPIRANT NON-AEROSOLS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | HENKEL AG & CO. KGAA (DE) | 2012-07-12 | — | — | US | disclosed |
| US-20120171143-A1 | WATER-FREE ANTIPERSPIRANT SPRAYS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | HENKEL AG & CO. KGAA (DE) | 2012-07-05 | — | — | US | disclosed |
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | HENKEL AG & CO. KGAA (DE) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | CUTA, NAPEPLD, LIPE | MEN1 2309/4885ALDH1A1 1032/4885HSPD1 3903/4885 |
| US-20120177589-A1 | WATER-FREE ANTIPERSPIRANT NON-AEROSOLS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | SIGMAR1, POLR1C, CUTA | MEN1 4381/4885ALDH1A1 2601/4885HSPD1 3852/4885 |
| US-20120171143-A1 | WATER-FREE ANTIPERSPIRANT SPRAYS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | POLR1C, CUTA, PHOSPHO1 | MEN1 2543/4885ALDH1A1 1827/4885HSPD1 3942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.