SCHEMBL4246580

SCHEMBL4246580

O=C(O)c1ccccc1Nc1ccc(Cl)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 3/20 0.71
AKR1C3 P42330 4/20 0.64
AKR1C2 P52895 3/20 0.64
TTR P02766 2/20 0.64
PTGS1 P23219 1/20 0.64
FTO Q9C0B1 2/20 0.61
MEN1 O00255 6/20 0.61
KMT2A Q03164 6/20 0.61
RECQL P46063 1/20 0.61
BLM P54132 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
MAPT P10636 4/20 0.59
ALDH1A1 P00352 2/20 0.59
TEAD4 Q15561 1/20 0.59
CYP1A2 P05177 2/20 0.58
CYP3A4 P08684 2/20 0.58
CYP2C19 P33261 2/20 0.58
GAA P10253 1/20 0.58
ALOX12 P18054 1/20 0.58
DHODH Q02127 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18109767 0.91 FABP4 (0.85) FABP4AKR1C3AKR1C2TTRPTGS1
SCHEMBL7841736 0.87 FABP4 (0.85) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL25828 0.87 FABP4 (0.92) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL29622832 0.87 FABP4 (0.92) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL3657701 0.85 FABP4 (0.89) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL28520019 0.85 FABP4 (0.89) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL10800939 0.85 FABP4 (0.89) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL27758639 0.85 FABP4 (0.89) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL11800213 0.85 FABP4 (0.89) FABP4AKR1C3AKR1C2TTRPTGS1
Fenamic Acid SCHEMBL27646881 0.85 FABP4 (0.89) FABP4AKR1C3AKR1C2TTRPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2009-05-21 US claimed
US-4921875-A Use of amino-substituted benzoic acids as remedies for diarrhea, and medicaments based on these compounds HOECHST AKTIENGESELLSCHAFT (DE) 1990-05-01 US claimed
US-20230381133-A1 TAU AND AMYLOID PROTEIN LOWERING COMPOUNDS AND METHODS OF USE HAMAD BIN KHALIFA UNIVERSITY (QA) 2023-11-30 US disclosed
US-20230381133-A1 TAU AND AMYLOID PROTEIN LOWERING COMPOUNDS AND METHODS OF USE HAMAD BIN KHALIFA UNIVERSITY (QA) 2023-11-30 US disclosed
US-20230381133-A1 TAU AND AMYLOID PROTEIN LOWERING COMPOUNDS AND METHODS OF USE HAMAD BIN KHALIFA UNIVERSITY (QA) 2023-11-30 US disclosed
CN-114585681-A Thermoplastic elastomer composition 陶氏环球技术有限责任公司 2022-06-03 CN disclosed
EP-3764416-B1 COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF DUK SAN NEOLUX CO LTD (KR) 2022-01-26 EP disclosed
US-20210013420-A1 COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME, AND ELECTRONIC DEVICE THEREOF DUK SAN NEOLUX CO., LTD. (KR) 2021-01-14 US disclosed
CN-105764883-B Thermoplastic polymer composition 美利肯公司 2019-06-04 CN disclosed
CN-105764883-A Thermoplastic polymer composition 美利肯公司 2016-07-13 CN disclosed
CN-105764971-A Thermoplastic polymer composition 美利肯公司 2016-07-13 CN disclosed
CN-105745264-A Thermoplastic polymer composition 美利肯公司 2016-07-06 CN disclosed
CN-105745189-A Thermoplastic polymer composition 美利肯公司 2016-07-06 CN disclosed
US-20150051286-A1 ANTHRANILIC ACID DERIVATIVES: NOVEL INHIBITORS OF ADVANCED GLYCATION END-PRODUCTS (AGES) FORMATION CHOUDHARY MUHAMMAD IQBAL (PK) 2015-02-19 US disclosed
US-20150051286-A1 ANTHRANILIC ACID DERIVATIVES: NOVEL INHIBITORS OF ADVANCED GLYCATION END-PRODUCTS (AGES) FORMATION CHOUDHARY MUHAMMAD IQBAL (PK) 2015-02-19 US disclosed
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2009-05-21 US disclosed
US-20060241108-A1 Substituted phenoxazines and acridones as inhibitors of AKT ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2006-10-26 US disclosed
WO-2006094207-A2 SUBSTITUTED PHENOXAZINES AND ACRIDONES AS INHIBITORS OF AKT ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2006-09-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210013420-A1 COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME, AND ELECTRONIC DEVICE THEREOF PIEZO1, ORAI2, OR10J3 FABP4 2297/4885AKR1C3 4381/4885AKR1C2 4062/4885
US-20150051286-A1 ANTHRANILIC ACID DERIVATIVES: NOVEL INHIBITORS OF ADVANCED GLYCATION END-PRODUCTS (AGES) FORMATION AGER, NFKBIA, DNPEP FABP4 228/4885AKR1C3 978/4885AKR1C2 734/4885
US-20090131527-A1 NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME CLIC1, ASIC1, CLIC4 FABP4 1600/4885AKR1C3 787/4885AKR1C2 477/4885
US-20230381133-A1 TAU AND AMYLOID PROTEIN LOWERING COMPOUNDS AND METHODS OF USE MAPT, TTR, HTT FABP4 1130/4885AKR1C3 3315/4885AKR1C2 3216/4885
US-20060241108-A1 Substituted phenoxazines and acridones as inhibitors of AKT AKT1S1, AKT3, PIK3CA FABP4 2313/4885AKR1C3 1303/4885AKR1C2 1345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.