Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067013 | 0.81 | KMT2A (0.60) | HSD17B10MAPTGAASMN1; SMN2RAB9A | |
| SCHEMBL7674468 | 0.71 | RAB9A (0.53) | MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7002930 | 0.71 | RAB9A (0.53) | MAPTSMN1; SMN2RAB9A | |
| SCHEMBL7676444 | 0.71 | FLT3 (0.55) | ALDH1A1MAPTHPGDL3MBTL1RAB9A | |
| SCHEMBL7002116 | 0.71 | FLT3 (0.46) | HSD17B10ALDH1A1MAPTHPGDL3MBTL1 | |
| SCHEMBL7005437 | 0.71 | PDE4D (0.46) | ALDH1A1MAPTHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL14585671 | 0.71 | ADRA2A (0.36) | HSD17B10ALDH1A1MAPTGAAHPGD | |
| SCHEMBL9409042 | 0.71 | JAK2 (0.58) | HSD17B10ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL1930005 | 0.70 | EPHB4 (0.40) | HSD17B10ALDH1A1MAPTGAAHPGD | |
| SCHEMBL2755842 | 0.69 | ALDH1A1 (0.77) | HSD17B10ALDH1A1MAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043654-A2 | THIENOPYRIMIDINES USEFUL AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals, Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146284-A2 | THIENOPYRIMIDINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-21 | — | — | WO | disclosed |