Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249587 | 1.00 | NOS1 (0.36) | NOS1L3MBTL1NPC1ALDH1A1CYP1A2 | |
| SCHEMBL24177802 | 0.89 | PCSK9 (0.33) | NOS1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL9012482 | 0.86 | NOS1 (0.38) | NOS1CTSK | |
| SCHEMBL14135 | 0.85 | RAB9A (0.32) | NOS1L3MBTL1RAB9A | |
| SCHEMBL13221 | 0.85 | RAB9A (0.32) | NOS1L3MBTL1RAB9A | |
| SCHEMBL8121 | 0.85 | RAB9A (0.32) | NOS1L3MBTL1RAB9A | |
| SCHEMBL8196578 | 0.81 | NOS1 (0.34) | NOS1 | |
| SCHEMBL2703386 | 0.80 | NOS1 (0.50) | NOS1 | |
| SCHEMBL13518677 | 0.80 | RAB9A (0.32) | NOS1L3MBTL1NPC1RAB9A | |
| SCHEMBL13518680 | 0.80 | RAB9A (0.32) | NOS1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |