SCHEMBL4250198

SCHEMBL4250198

O=C(NC(=O)N1CCC(Cc2ccc(C(F)(F)F)cc2)CC1)c1ccc(O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.53
HIF1A Q16665 1/20 0.53
EPAS1 Q99814 1/20 0.53
MGLL Q99685 1/20 0.46
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
LMNA P02545 1/20 0.45
GRIN2D O15399 1/20 0.45
GRIN3B O60391 1/20 0.45
GRIN1 Q05586 1/20 0.45
GRIN2A Q12879 1/20 0.45
GRIN2B Q13224 1/20 0.45
GRIN2C Q14957 1/20 0.45
GRIN3A Q8TCU5 1/20 0.45
FAAH O00519 2/20 0.44
CCR3 P51677 1/20 0.44
CCR5 P51681 1/20 0.44
ME2 P23368 1/20 0.44
ME1 P48163 1/20 0.44
ME3 Q16798 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4244566 0.89 ESRRG (0.49) KMT2AMEN1GRIN2DGRIN3BGRIN1
SCHEMBL4243146 0.88 CCR3 (0.49) KMT2AMEN1GRIN2DGRIN3BGRIN1
SCHEMBL4247871 0.86 KMT2A (0.62) MGLLKMT2AMEN1GRIN2DGRIN3B
SCHEMBL4243510 0.86 FAAH (0.56) MGLLKMT2AMEN1LMNAGRIN2D
SCHEMBL4239616 0.86 FAAH (0.61) KMT2AMEN1GRIN2DGRIN3BGRIN1
SCHEMBL4252214 0.84 KMT2A (0.47) KMT2AMEN1GRIN2DGRIN3BGRIN1
SCHEMBL4241032 0.83 SMN1; SMN2 (0.59) MGLLKMT2AMEN1GRIN1GRIN2B
SCHEMBL5320489 0.83 KMT2A (0.46) KMT2AMEN1GRIN2DGRIN3BGRIN1
SCHEMBL4250202 0.81 GAA (0.52) SLC2A1HIF1AEPAS1MGLLGRIN2D
SCHEMBL4239655 0.80 F2 (0.50) MGLLKMT2AMEN1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170901-A1 Benzoyl Urea Derivatives RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2009-07-02 US claimed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP claimed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO claimed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP disclosed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170901-A1 Benzoyl Urea Derivatives OPRM1, GRIN2C, GRIN3A SLC2A1 1948/4885HIF1A 2333/4885EPAS1 2850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.