SCHEMBL4247871

SCHEMBL4247871

O=C(NC(=O)N1CCC(Cc2ccc(Cl)cc2)CC1)c1ccc(O)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.62
POLB P06746 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
FAAH O00519 2/20 0.47
GRIN2D O15399 1/20 0.46
GRIN3B O60391 1/20 0.46
GRIN1 Q05586 1/20 0.46
GRIN2A Q12879 1/20 0.46
GRIN2B Q13224 1/20 0.46
GRIN2C Q14957 1/20 0.46
GRIN3A Q8TCU5 1/20 0.46
MEN1 O00255 2/20 0.46
MGLL Q99685 2/20 0.46
ALOX5 P09917 1/20 0.46
NPC1 O15118 1/20 0.46
CYP1A2 P05177 1/20 0.46
GAA P10253 1/20 0.46
CYP2D6 P10635 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4243146 0.88 CCR3 (0.49) KMT2AGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL4243510 0.88 FAAH (0.56) KMT2APOLBFAAHGRIN2DGRIN3B
SCHEMBL4239616 0.88 FAAH (0.61) KMT2APOLBFAAHGRIN2DGRIN3B
SCHEMBL4252214 0.86 KMT2A (0.47) KMT2APOLBSMN1; SMN2FAAHGRIN2D
SCHEMBL4250198 0.86 SLC2A1 (0.53) KMT2AFAAHGRIN2DGRIN3BGRIN1
SCHEMBL4244566 0.86 ESRRG (0.49) KMT2APOLBFAAHGRIN2DGRIN3B
SCHEMBL4241032 0.85 SMN1; SMN2 (0.59) KMT2APOLBSMN1; SMN2GRIN1GRIN2B
SCHEMBL5320489 0.85 KMT2A (0.46) KMT2AFAAHGRIN2DGRIN3BGRIN1
SCHEMBL5165692 0.84 ADAMTS5 (0.60) KMT2APOLBSMN1; SMN2FAAHMEN1
SCHEMBL5284883 0.83 FAAH (0.62) KMT2APOLBSMN1; SMN2FAAHGRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170901-A1 Benzoyl Urea Derivatives RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2009-07-02 US claimed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP claimed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO claimed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP disclosed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170901-A1 Benzoyl Urea Derivatives OPRM1, GRIN2C, GRIN3A KMT2A 3249/4885POLB 2381/4885SMN1; SMN2 3077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.