Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6418155 | 0.88 | ATM (0.41) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL2474145 | 0.83 | ATM (0.44) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL2621291 | 0.71 | MAPT (0.70) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL31276462 | 0.71 | MAPT (0.70) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| Bromide SCHEMBL9239377 | 0.69 | MAPT (0.68) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL29531707 | 0.68 | NPC1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL824375 | 0.68 | NPC1 (0.69) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL11769878 | 0.68 | MAPT (0.50) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL2147139 | 0.68 | RAB9A (0.66) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL2147609 | 0.68 | RAB9A (0.66) | NPC1RAB9AMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499616-B1 | HETEROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |
| US-7417050-B2 | Cognition activators; Alzheimer's disease; attention deficit disorders; Parkinson's disease; Huntington's disease; neurodegenerative disease | ASTRAZENECA AB (SE) | 2008-08-26 | — | — | US | disclosed |
| US-20050131003-A1 | Heterocyclic compounds | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131003-A1 | Heterocyclic compounds | AR, MC2R, CYP11B2 | NPC1 396/4885RAB9A 1229/4885MAPT 2922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.