Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261648 | 0.88 | NPC1 (0.48) | TDP1MAPTALDH1A1KMT2AHSD17B10 | |
| SCHEMBL2474145 | 0.82 | ATM (0.44) | ATMTDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL591905 | 0.67 | RAB9A (0.72) | MAPTALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL30184671 | 0.67 | RAB9A (0.72) | MAPTALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL439174 | 0.66 | MAPT (0.70) | MAPTALDH1A1KMT2AHSD17B10LMNA | |
| Benzene SCHEMBL28280876 | 0.66 | RAB9A (0.70) | MAPTALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL6416075 | 0.65 | FAAH (0.32) | FAAHCES1 | |
| SCHEMBL2567453 | 0.65 | MAPT (0.68) | MAPTALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL11623669 | 0.65 | MAPT (0.68) | MAPTALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL14402606 | 0.65 | MAPT (0.68) | MAPTALDH1A1KMT2AHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499616-A1 | HETEROCYCLIC COMPOUNDS | AstraZeneca AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003087104-A1 | HETEROCYCLIC COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-23 | — | — | WO | disclosed |