Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | CLPP | Q16740 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4263514 | 0.88 | HSD11B1 (0.40) | HSD11B1LMNAGAAHDAC3CYP2C9 | |
| SCHEMBL4263224 | 0.79 | CTSK (0.41) | HSD11B1 | |
| SCHEMBL5013452 | 0.79 | METAP2 (0.37) | DRD4PTGER4CASRLMNAGAA | |
| SCHEMBL4262148 | 0.77 | PNKP (0.39) | HSD11B1LMNA | |
| SCHEMBL12184423 | 0.75 | HIF1A (0.46) | HDAC1 | |
| SCHEMBL12184868 | 0.75 | DRD4 (0.47) | DRD4CLPP | |
| SCHEMBL4257406 | 0.72 | HDAC6 (0.43) | LMNAHDAC6 | |
| SCHEMBL12184355 | 0.72 | KCNH2 (0.47) | LMNA | |
| SCHEMBL12184599 | 0.71 | HSD11B1 (0.45) | HSD11B1PTGER4HDAC1 | |
| SCHEMBL12184992 | 0.71 | ALDH1A1 (0.54) | GAAHDAC3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |