Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL7573233 | 1.00 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL10906789 | 1.00 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL7574684 | 1.00 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL7569002 | 1.00 | CA4 (0.94) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL29094234 | 0.97 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL30697337 | 0.97 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL21815132 | 0.97 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL123089 | 0.97 | CA4 (1.00) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL11056334 | 0.94 | CA4 (0.89) | CA4CA2CTSLSLC22A16CASP1 | |
| Malic Acid SCHEMBL11599545 | 0.94 | CA4 (0.89) | CA4CA2CTSLSLC22A16CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026098867-A1 | OXIDATIVE HAIR BRIGHTENING BY MEANS OF PERSULFATE, DICARBOXYLIC ACID, AND CITRULLINE | HENKEL AG & CO. KGAA (DE) | 2026-05-15 | — | — | WO | disclosed |
| EP-4630123-A1 | MULTI-COMPONENT PACKAGING UNIT COMPRISING A FIRST PREPARATION (A) HAVING PEROXODISULPHATE, DI- OR TRICARBOXYLIC ACID AND AMINO ACID AND A SECOND PREPARATION (B) HAVING CARBAMIDE PEROXIDE | Henkel AG & Co. KGaA (DE) | 2025-10-15 | — | — | EP | disclosed |
| EP-4514306-A1 | OXIDATIVE HAIR-LIGHTENING AGENTS HAVING IMPROVED APPLICATION PROPERTIES FOR BLEACHING HAIR ROOTS | Henkel AG & Co. KGaA (DE) | 2025-03-05 | — | — | EP | disclosed |
| EP-4475813-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | Henkel AG & Co. KGaA (DE) | 2024-12-18 | — | — | EP | disclosed |
| US-20240390245-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | HENKEL AG & CO. KGAA (DE) | 2024-11-28 | — | — | US | disclosed |
| WO-2024120663-A1 | MULTI-COMPONENT PACKAGING UNIT COMPRISING A FIRST PREPARATION (A) HAVING PEROXODISULPHATE, DI- OR TRICARBOXYLIC ACID AND AMINO ACID AND A SECOND PREPARATION (B) HAVING CARBAMIDE PEROXIDE | HENKEL AG & CO. KGAA (DE) | 2024-06-13 | — | — | WO | disclosed |
| WO-2023208489-A1 | OXIDATIVE HAIR-LIGHTENING AGENTS HAVING IMPROVED APPLICATION PROPERTIES FOR BLEACHING HAIR ROOTS | HENKEL AG & CO. KGAA (DE) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023208488-A1 | OXIDATIVE HAIR LIGHTENING PRODUCT WITH CONTROLLED SWELLING BEHAVIOR | HENKEL AG & CO. KGAA (DE) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023151873-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | HENKEL AG & CO. KGAA (DE) | 2023-08-17 | — | — | WO | disclosed |
| US-11661511-B2 | Production method of polyacetal resin composition | POLYPLASTICS CO., LTD. (JP) | 2023-05-30 | — | — | US | disclosed |
| US-20210169755-A1 | DUST REDUCED AMMONIUM FREE BLONDING POWDER | HENKEL AG & CO. KGAA (DE) | 2021-06-10 | — | — | US | disclosed |
| US-20210169762-A1 | AMMONIA-FREE BLEACHING KIT FOR GENTLE BRIGHTENING OF KERATINOUS FIBERS | HENKEL AG & CO. KGAA (DE) | 2021-06-10 | — | — | US | disclosed |
| US-20200206104-A1 | USE OF SODIUM CHLORIDE IN BLEACHING AGENTS BASED ON PRECARBONATE FOR HUMAN HAIR APPLICATION | HENKEL AG & CO. KGAA (DE) | 2020-07-02 | — | — | US | disclosed |
| US-20200206100-A1 | THICKENING SYSTEM IN A PERCARBONATE-CONTAINING BLONDING AGENT | HENKEL AG & CO. KGAA (DE) | 2020-07-02 | — | — | US | disclosed |
| WO-2020135954-A1 | BLEACHING AGENTS IN AN ALUMINIUM SACHET | HENKEL AG & CO. KGAA (DE) | 2020-07-02 | — | — | WO | disclosed |
| US-20180008524-A1 | BLEACHING AGENT AND METHOD FOR GENTLE OXIDATIVE LIGHTENING OF KERATIN FIBRES | HENKEL AG & CO. KGAA (DE) | 2018-01-11 | — | — | US | disclosed |
| US-20170340549-A1 | BLONDING AGENT AND METHOD FOR GENTLE OXIDATIVE HAIR LIGHTENING | HENKEL AG & CO. KGAA (DE) | 2017-11-30 | — | — | US | disclosed |
| US-20170340553-A1 | PASTE-LIKE BLEACHING AGENT AND METHOD FOR GENTLE OXIDATIVE HAIR LIGHTENING | HENKEL AG & CO. KGAA (DE) | 2017-11-30 | — | — | US | disclosed |
| EP-1825763-B1 | Method of removing nitric acid from aqueous liquid and method of producing drinks | ITO EN LTD (JP) | 2009-11-04 | — | — | EP | disclosed |
| EP-1825763-A1 | Method of removing nitric acid from aqueous liquid and method of producing drinks | Ito En, Ltd. (JP) | 2007-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240390245-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | GPX4, TYR, GPX1 | CA4 950/4885CA2 465/4885CTSL 3503/4885 |
| US-20200206100-A1 | THICKENING SYSTEM IN A PERCARBONATE-CONTAINING BLONDING AGENT | KRT18, DSG1, POLR1C | CA4 3277/4885CA2 1406/4885CTSL 3796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.