Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | FAAH | O00519 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169009 | 0.96 | NR5A1 (0.62) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL24398901 | 0.94 | NR5A1 (0.66) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL10825058 | 0.94 | NR5A1 (0.66) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL15924079 | 0.94 | NR5A1 (0.66) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL13106427 | 0.92 | TSHR (0.66) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL171915 | 0.91 | L3MBTL1 (0.60) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL8377181 | 0.90 | TSHR (0.55) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7176783 | 0.90 | CYP2D6 (0.59) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL8909093 | 0.88 | L3MBTL1 (0.58) | TSHRFAAHCYP2D6CYP1A2CYP2C19 | |
| SCHEMBL10338308 | 0.87 | MEN1 (0.60) | TSHRCYP2D6CYP1A2CYP2C19TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225119-A1 | STABILIZATION OF INTEGRIN INHIBITORS | PLIANT THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |
| US-20230312587-A1 | PTERIDINONE COMPOUNDS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2023-10-05 | — | — | US | disclosed |
| US-11572364-B2 | Pteridinone compounds and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-02-07 | — | — | US | disclosed |
| EP-3783000-B1 | MACROCYCLIC KINASE INHIBITOR | HITGEN INC (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3783000-A1 | MACROCYCLIC KINASE INHIBITOR | Hitgen Inc. (CN) | 2021-02-24 | — | — | EP | disclosed |
| WO-2020210919-A1 | NOVEL RADIOLABELLED CXCR4-TARGETING COMPOUNDS FOR DIAGNOSIS AND THERAPY | PROVINCIAL HEALTH SERVICES AUTHORITY (CA) | 2020-10-22 | — | — | WO | disclosed |
| US-20200223871-A1 | Arginase Inhibitors and Methods of Use | ASTRAZENECA AB (SE) | 2020-07-16 | — | — | US | disclosed |
| WO-2019201282-A1 | MACROCYCLIC KINASE INHIBITOR | 成都先导药物开发股份有限公司 | 2019-10-24 | — | — | WO | disclosed |
| US-20190241532-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | FORMA THERAPEUTICS, INC. | 2019-08-08 | — | — | US | disclosed |
| EP-2389352-B1 | ARGINASE INHIBITORS AND METHODS OF USE | UNIV PENNSYLVANIA (US) | 2019-05-08 | — | — | EP | disclosed |
| US-20100004459-A1 | 2-PHENYLNICOTINIC ACID DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2010-01-07 | — | — | US | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| US-7402674-B2 | 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH, (DE) | 2008-07-22 | — | — | US | disclosed |
| US-7365196-B2 | Sulphonamido-substituted bridged bicycloalkyl derivatives | MERCK SHARP & DOHME LTD. (GB) | 2008-04-29 | — | — | US | disclosed |
| US-7365196-B2 | Sulphonamido-substituted bridged bicycloalkyl derivatives | MERCK SHARP & DOHME LTD. (GB) | 2008-04-29 | — | — | US | disclosed |
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |
| US-7169786-B2 | Isoxazoline derivatives as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2007-01-30 | — | — | US | disclosed |
| US-7169786-B2 | Isoxazoline derivatives as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2007-01-30 | — | — | US | disclosed |
| EP-0575361-A1 | NEW 1-ARYL-4-PIPERAZINYL-CYCLOHEXANECARBOXYLIC ACID NITRILES, THEIR PRODUCTION AND THEIR USE. | BASF AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| WO-1992016516-A1 | NEW 1-ARYL-4-PIPERAZINYL-CYCLOHEXANECARBOXYLIC ACID NITRILES, THEIR PRODUCTION AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 1992-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572364-B2 | Pteridinone compounds and uses thereof | DPYD, PKD1, TYMP | TSHR 3747/4885FAAH 4576/4885CYP2D6 1271/4885 |
| US-20200223871-A1 | Arginase Inhibitors and Methods of Use | ARG1, ARG2, NOS2 | TSHR 2581/4885FAAH 1697/4885CYP2D6 1369/4885 |
| US-20100004459-A1 | 2-PHENYLNICOTINIC ACID DERIVATIVE | XDH, NUDT1, PNPO | TSHR 3147/4885FAAH 1558/4885CYP2D6 616/4885 |
| US-20230312587-A1 | PTERIDINONE COMPOUNDS AND USES THEREOF | DPYD, PKD1, TYMP | TSHR 3747/4885FAAH 4576/4885CYP2D6 1271/4885 |
| US-20190241532-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | FASN, FABP1, SCD | TSHR 3727/4885FAAH 42/4885CYP2D6 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.