Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 7/20 | 0.67 |
| ▸ | TNF | P01375 | 4/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 1/20 | 0.67 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.58 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10346506 | 0.89 | ADORA2B (0.63) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL10346307 | 0.89 | LMNA (0.61) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL18174522 | 0.88 | ADORA2B (0.65) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL17682156 | 0.88 | ADORA2B (0.62) | ADORA2BTNFUSP2LMNACYP1A2 | |
| Bisdionin D SCHEMBL16120988 | 0.88 | ADORA2B (0.79) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL17682126 | 0.88 | ADORA2B (0.65) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL10346304 | 0.86 | LMNA (0.56) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL10346585 | 0.86 | PDE4A (0.60) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL19601304 | 0.86 | PDE4A (0.58) | ADORA2BTNFUSP2LMNACYP1A2 | |
| SCHEMBL16120981 | 0.86 | ADORA2B (0.77) | ADORA2BTNFUSP2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432968-B1 | IMMUNOSUPPRESSANTS FOR PATIENTS WITH CANCER, AUTOIMMUNE DISEASES, AND VIRAL INFECTIONS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-13 | — | — | US | claimed |
| EP-0797448-A2 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-01 | — | — | EP | claimed |
| US-5585380-A | ADMINISTERING XANTHINE DERIVATIVE | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1996-12-17 | — | — | US | claimed |
| WO-1996005854-A2 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-29 | — | — | WO | claimed |
| EP-0573617-A4 | — | — | 1994-02-09 | — | — | EP | claimed |
| EP-0573617-A1 | MODULATION OF CELLULAR RESPONSE TO EXTERNAL STIMULI | Fred Hutchinson Cancer Research Center (US) | 1993-12-15 | — | — | EP | claimed |
| WO-1992021344-A2 | MODULATION OF CELLULAR RESPONSE TO EXTERNAL STIMULI | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1992-12-10 | — | — | WO | claimed |
| US-9493463-B2 | Substituted xanthine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20150322068-A1 | SUBSTITUTED XANTHINE DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2015-11-12 | — | — | US | disclosed |
| US-9035050-B2 | Substituted xanthine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2015-05-19 | — | — | US | disclosed |
| US-20140121226-A1 | SUBSTITUTED XANTHINE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2014-05-01 | — | — | US | disclosed |
| US-20090258860-A1 | XANTHINE DERIVATIVES FOR THE TREATMENT OF VASCULAR DEPRESSION | DUKE UNIVERSITY (US) | 2009-10-15 | — | — | US | disclosed |
| US-20090239886-A1 | Substituted xanthine derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2009-09-24 | — | — | US | disclosed |
| US-5585380-A | ADMINISTERING XANTHINE DERIVATIVE | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1996-12-17 | — | — | US | disclosed |
| WO-1996005854-A2 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-29 | — | — | WO | disclosed |
| EP-0573617-A4 | — | — | 1994-02-09 | — | — | EP | disclosed |
| EP-0573617-A1 | MODULATION OF CELLULAR RESPONSE TO EXTERNAL STIMULI | Fred Hutchinson Cancer Research Center (US) | 1993-12-15 | — | — | EP | disclosed |
| WO-1992021344-A2 | MODULATION OF CELLULAR RESPONSE TO EXTERNAL STIMULI | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1992-12-10 | — | — | WO | disclosed |
| EP-0268585-B1 | TERTIARY HYDROXYALKYLXANTHINES, THEIR MANUFACTURING PROCESS, MEDICINES CONTAINING THEM AND USE THEREOF | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |
| US-4833146-A | BRAINS, BLOOD DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322068-A1 | SUBSTITUTED XANTHINE DERIVATIVES | XDH, HPRT1, CXCR3 | ADORA2B 60/4885TNF 583/4885USP2 4016/4885 |
| US-20090258860-A1 | XANTHINE DERIVATIVES FOR THE TREATMENT OF VASCULAR DEPRESSION | TPH1, HTR5A, XDH | ADORA2B 52/4885TNF 361/4885USP2 4157/4885 |
| US-20090239886-A1 | Substituted xanthine derivatives | XDH, HPRT1, CXCR3 | ADORA2B 60/4885TNF 583/4885USP2 4016/4885 |
| US-20140121226-A1 | SUBSTITUTED XANTHINE DERIVATIVES | XDH, CXCR4, CXCR3 | ADORA2B 24/4885TNF 1024/4885USP2 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.