Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1675988 | 0.85 | RAB9A (0.71) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| Cuneatin SCHEMBL29818214 | 0.84 | KDM4E (0.67) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| Glaziovianin A SCHEMBL29402459 | 0.80 | ACHE (0.49) | SMN1; SMN2ACHERAB9AMAPTNPC1 | |
| SCHEMBL29378746 | 0.76 | MAPT (0.53) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| SCHEMBL571676 | 0.76 | HDAC6 (0.61) | SMN1; SMN2ACHERAB9AMAPTNPC1 | |
| SCHEMBL29365787 | 0.75 | RAB9A (0.67) | SMN1; SMN2ACHERAB9AMAPTNPC1 | |
| SCHEMBL28314002 | 0.73 | NPC1 (0.53) | ACHERAB9AMAPTNPC1HSD17B10 | |
| SCHEMBL10564937 | 0.73 | RAB9A (0.72) | SMN1; SMN2ACHERAB9AMAPTNPC1 | |
| Ichthynone SCHEMBL29934702 | 0.73 | BCHE (0.60) | SMN1; SMN2MAPTLMNACYP3A4HSD17B10 | |
| Ichthynone SCHEMBL9924621 | 0.73 | BCHE (0.60) | SMN1; SMN2MAPTLMNACYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PC, PCK2, CS | SMN1; SMN2 281/4885ACHE 865/4885RAB9A 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.