Sugi Predict

Sugi Predict / Compounds / SCHEMBL428406

SCHEMBL428406

SCHEMBL428406

N#Cc1ccc([N+](=O)[O-])c(NC2CC2)c1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.58
▸ KMT2A Q03164 3/20 0.58
▸ L3MBTL1 Q9Y468 1/20 0.58
▸ MAPT P10636 6/20 0.56
▸ MAPK1 P28482 2/20 0.56
▸ CYP1A2 P05177 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ HTT P42858 1/20 0.55
▸ GAA P10253 2/20 0.53
▸ GLA P06280 1/20 0.53
▸ HCAR3 P49019 3/20 0.49
▸ VCAM1 P19320 2/20 0.49
▸ ALDH1A1 P00352 1/20 0.46
▸ KAT2B Q92831 1/20 0.44
▸ MERTK Q12866 1/20 0.43
▸ DCTPP1 Q9H773 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.41
▸ POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29526088 1.00 MEN1 (0.58) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL30734277 0.94 MEN1 (0.63) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL17582877 0.94 MEN1 (0.63) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL8248585 0.88 HCAR3 (0.59) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL20572221 0.87 KMT2A (0.48) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL20572039 0.87 MAPT (0.49) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL20571777 0.87 MEN1 (0.48) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL20571173 0.86 KMT2A (0.47) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL26310307 0.86 KMT2A (0.47) MEN1KMT2AL3MBTL1MAPTMAPK1
SCHEMBL26310300 0.86 KMT2A (0.47) MEN1KMT2AL3MBTL1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260097034-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LTD (HK) 2026-04-09 — — US disclosed
US-12458642-B2 Metalloenzyme inhibitor compounds CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2025-11-04 — — US disclosed
US-20250296925-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LTD (HK) 2025-09-25 — — US disclosed
US-12358893-B2 Metalloenzyme inhibitor compounds CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2025-07-15 — — US disclosed
EP-3562306-B1 METALLOENZYME INHIBITOR COMPOUNDS JI XING PHARMACEUTICALS HONG KONG LTD (HK) 2025-02-26 — — EP disclosed
US-11919883-B2 Metalloenzyme inhibitor compounds JI XING PHARMACEUTICALS HONG KONG LIMITED (HK) 2024-03-05 — — US disclosed
EP-4311577-A2 METALLOENZYME INHIBITOR COMPOUNDS Ji Xing Pharmaceuticals Hong Kong Limited (HK) 2024-01-31 — — EP disclosed
EP-3562487-B1 METALLOENZYME INHIBITOR COMPOUNDS JI XING PHARMACEUTICALS HONG KONG LTD (HK) 2023-11-29 — — EP disclosed
EP-3908319-B1 METALLOENZYME INHIBITOR COMPOUNDS JI XING PHARMACEUTICALS HONG KONG LTD (HK) 2023-10-18 — — EP disclosed
CN-114269383-A Metalloenzyme inhibitor compounds 菲斯生物制药公司 2022-04-01 — — CN disclosed
US-20180185362-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2018-07-05 — — US disclosed
US-20180186773-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2018-07-05 — — US disclosed
US-20180186773-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2018-07-05 — — US disclosed
US-20180185362-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2018-07-05 — — US disclosed
WO-2018125799-A2 METALLOENZYME INHIBITOR COMPOUNDS VIAMET PHARMACEUTICALS (BERMUDA), LTD. (BM) 2018-07-05 — — WO disclosed
US-9382226-B2 Aldosterone synthase inhibitors MERCK SHARP & DOHME CORP. (US) 2016-07-05 — — US disclosed
US-9382226-B2 Aldosterone synthase inhibitors MERCK SHARP & DOHME CORP. (US) 2016-07-05 — — US disclosed
US-20130317057-A1 ALDOSTERONE SYNTHASE INHIBITORS MERCK SHARP & DOHME LLC 2013-11-28 — — US disclosed
EP-2595482-A1 ALDOSTERONE SYNTHASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2013-05-29 — — EP disclosed
WO-2012012478-A1 ALDOSTERONE SYNTHASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2012-01-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12358893-B2 Metalloenzyme inhibitor compounds SOD1, RNASE1, FECH MEN1 720/4885KMT2A 2849/4885L3MBTL1 1019/4885
US-12458642-B2 Metalloenzyme inhibitor compounds CYP11B2, CYP11B1, HSD11B2 MEN1 839/4885KMT2A 1496/4885L3MBTL1 2843/4885
US-20180185362-A1 METALLOENZYME INHIBITOR COMPOUNDS SOD1, RNASE1, FECH MEN1 720/4885KMT2A 2849/4885L3MBTL1 1019/4885
US-20250296925-A1 METALLOENZYME INHIBITOR COMPOUNDS SOD1, RNASE1, FECH MEN1 720/4885KMT2A 2849/4885L3MBTL1 1019/4885
US-20180186773-A1 METALLOENZYME INHIBITOR COMPOUNDS SOD1, RNASE1, FECH MEN1 720/4885KMT2A 2849/4885L3MBTL1 1019/4885
US-20260097034-A1 METALLOENZYME INHIBITOR COMPOUNDS CPN1, TPP1, DPP4 MEN1 1831/4885KMT2A 2003/4885L3MBTL1 2723/4885
US-20130317057-A1 ALDOSTERONE SYNTHASE INHIBITORS HSD11B1, CYP11B2, HSD11B2 MEN1 2267/4885KMT2A 3098/4885L3MBTL1 4504/4885
US-11919883-B2 Metalloenzyme inhibitor compounds SOD1, RNASE1, FECH MEN1 720/4885KMT2A 2849/4885L3MBTL1 1019/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.