Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283330 | 0.83 | RBP4 (0.35) | — | |
| SCHEMBL9542593 | 0.83 | NOTUM (0.43) | NOTUMALDH1A1 | |
| SCHEMBL25221357 | 0.82 | CYP1A2 (0.43) | NOTUMCYP1A2CYP2C19 | |
| SCHEMBL26103110 | 0.81 | NOTUM (0.45) | NOTUMALDH1A1 | |
| SCHEMBL25268555 | 0.81 | NOTUM (0.45) | NOTUMALDH1A1 | |
| SCHEMBL4284699 | 0.81 | FNTA (0.41) | — | |
| SCHEMBL4563464 | 0.78 | HDAC1 (0.33) | — | |
| SCHEMBL9543218 | 0.77 | CYP1A2 (0.44) | NOTUMNPC1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7993369 | 0.77 | DRD2 (0.54) | NOTUMNPC1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5556232 | 0.76 | PKM (0.51) | NOTUMNPC1ALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151626-A1 | SUBSTITUTED (1, 2, 4-0XADIAZ0L-3-YL) INDOLIN-1-YL CARBOXYLIC ACID DERIVATIVES USEFUL AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |