Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204053 | 0.87 | NOTUM (0.64) | DRD2DRD4NOTUMALDH1A1NPC1 | |
| SCHEMBL4289075 | 0.85 | DRD2 (0.53) | DRD2DRD4NOTUMALDH1A1NPC1 | |
| SCHEMBL30681441 | 0.85 | DRD2 (0.53) | DRD2DRD4NOTUMALDH1A1NPC1 | |
| SCHEMBL7554164 | 0.85 | DRD2 (0.53) | DRD2DRD4NOTUMALDH1A1NPC1 | |
| SCHEMBL8018491 | 0.84 | MTNR1A (0.51) | ACE | |
| SCHEMBL5556232 | 0.84 | PKM (0.51) | NOTUMALDH1A1NPC1CYP1A2CYP2C19 | |
| SCHEMBL30681525 | 0.83 | NOTUM (0.48) | NOTUMALDH1A1NPC1CYP1A2CYP2C19 | |
| SCHEMBL18701883 | 0.83 | DRD2 (0.51) | DRD2DRD4NOTUMALDH1A1NPC1 | |
| SCHEMBL4386325 | 0.80 | NOTUM (0.44) | NOTUMALDH1A1NPC1CYP1A2CYP2C19 | |
| SCHEMBL4436739 | 0.79 | NOTUM (0.43) | DRD2DRD4NOTUMACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281240-B1 | CYSTIC FIBROSIS | ELI LILLY AND COMPANY | 2001-08-28 | — | — | US | disclosed |
| WO-1998044799-A1 | DIARYLSULFONYLUREAS FOR USE IN TREATING SECRETORY DIARRHEA | ELI LILLY AND COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0606723-A1 | Imidazolidin-2-one derivatives and their use as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-07-20 | — | — | EP | disclosed |
| US-5270329-A | 1-arylsulfonyl-imidazolidin-2-one derivatives | ELI LILLY AND COMPANY (US) | 1993-12-14 | — | — | US | disclosed |