Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2498385 | 0.85 | NPC1 (0.72) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL1194336 | 0.80 | TRPM8 (0.59) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL9256013 | 0.80 | ALDH1A1 (0.70) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL12324407 | 0.79 | NPC1 (0.50) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL1808600 | 0.79 | ALDH1A1 (0.58) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL15182513 | 0.79 | NPC1 (0.52) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL21771163 | 0.79 | NPC1 (0.52) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL7940870 | 0.79 | NPC1 (0.52) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL12661708 | 0.79 | LMNA (0.67) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL20654264 | 0.77 | NPC1 (0.51) | NPC1ALDH1A1HPGDCYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284286-B2 | Specific carboxamides as KCNQ2/3 modulators | Grünenthal GmbH (DE) | 2016-03-15 | — | — | US | disclosed |
| EP-2951156-A1 | SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014082737-A1 | SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2014-06-05 | — | — | WO | disclosed |
| US-20140148468-A1 | SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-08 | — | — | US | disclosed |
| EP-1971596-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | Takeda Pharmaceutical Company Limited (JP) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |
| EP-0095925-B2 | Herbicidal imidazole, pyrazole, thiazole and isothiazole derivatives | DU PONT (US) | 1994-12-07 | — | — | EP | disclosed |
| US-4943312-A | Herbicidal thiazole derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-07-24 | — | — | US | disclosed |
| US-4919706-A | HERBICIDES; PLANT GROWTH REGULATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0095925-B1 | HERBICIDAL IMIDAZOLE, PYRAZOLE, THIAZOLE AND ISOTHIAZOLE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-03-22 | — | — | EP | disclosed |
| EP-0095925-A2 | Herbicidal imidazole, pyrazole, thiazole and isothiazole derivatives | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-12-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148468-A1 | SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS | KCNQ1, KCNQ2, KCNQ3 | NPC1 2944/4885ALDH1A1 3964/4885HPGD 3233/4885 |
| US-20090253687-A1 | Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands | NR3C2, NR3C1, MC2R | NPC1 2803/4885ALDH1A1 2708/4885HPGD 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.