Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | GPR3 | P46089 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767091 | 0.82 | ALDH1A1 (0.47) | PDE10AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL11214071 | 0.82 | PDE10A (0.44) | PDE10AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL6081732 | 0.82 | PDE10A (0.44) | PDE10AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL9384223 | 0.82 | DDAH1 (0.58) | PDE10AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL3123736 | 0.80 | ALDH1A1 (0.50) | PDE10AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL9178002 | 0.79 | GAA (0.60) | PDE10AALDH1A1KDM4EHPGDGAA | |
| SCHEMBL9179087 | 0.79 | RAB9A (0.50) | PDE10AALDH1A1KDM4EHPGDGLA | |
| SCHEMBL8626590 | 0.78 | EGFR (0.46) | PDE10AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL8501957 | 0.77 | PARP1 (0.60) | PDE10AALDH1A1KDM4EHPGDGLA | |
| SCHEMBL7655532 | 0.77 | ALDH1A1 (0.41) | PDE10AALDH1A1KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124641-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | disclosed |
| US-20090124641-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | disclosed |
| CN-101106998-A | Mitotic kinesin inhibitors | MERCK & CO INC (US) | 2008-01-16 | — | — | CN | disclosed |
| EP-1855685-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1855685-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006078598-A3 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2006078598-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2006-07-27 | — | — | WO | disclosed |
| WO-2006078598-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124641-A1 | Mitotic Kinesin Inhibitors | KIF5B, KIF2C, KIF18B | PDE10A 4500/4885ALDH1A1 2729/4885KDM4E 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.