Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.70 |
| ▸ | KDR | P35968 | 5/20 | 0.70 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.55 |
| ▸ | IL1RN | P18510 | 1/20 | 0.55 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.55 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16854979 | 0.86 | EGFR (0.54) | EGFRFGFR1KDRMEN1ALDH1A1 | |
| SCHEMBL9953226 | 0.85 | KEAP1 (0.54) | EGFRFGFR1KDRKEAP1MEN1 | |
| SCHEMBL1850850 | 0.84 | EGFR (0.53) | EGFRFGFR1KDRMEN1ALDH1A1 | |
| SCHEMBL15219418 | 0.84 | EGFR (0.59) | EGFRFGFR1KDRKEAP1IL1RN | |
| SCHEMBL4285713 | 0.79 | EGFR (0.70) | EGFRFGFR1KDRKEAP1IL1RN | |
| SCHEMBL4561123 | 0.76 | EGFR (0.53) | EGFRFGFR1KDR | |
| SCHEMBL4282959 | 0.76 | TAS2R8 (0.63) | EGFRFGFR1KDRKEAP1IL1RN | |
| SCHEMBL28439897 | 0.75 | DHX9 (0.51) | EGFRFGFR1KDRKEAP1MEN1 | |
| Hydrochloric Acid SCHEMBL29505563 | 0.73 | ALDH1A1 (0.44) | EGFRFGFR1KDRALDH1A1CA12 | |
| SCHEMBL31011096 | 0.73 | HTT (0.47) | EGFRFGFR1KDRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156582-A1 | Pyrazole Compound | GSK3B, GSK3A, GSKIP | EGFR 4685/4885FGFR1 2577/4885KDR 3635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.