Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PRF1 | P14222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4289381 | 0.85 | EGFR (0.70) | KEAP1NFE2L2EGFRFGFR1KDR | |
| SCHEMBL16854979 | 0.78 | EGFR (0.54) | EGFRFGFR1KDRKMT2AGAA | |
| SCHEMBL2565637 | 0.77 | KEAP1 (0.64) | KEAP1NFE2L2KMT2AGAAPOLB | |
| SCHEMBL784141 | 0.77 | KEAP1 (0.66) | KEAP1NFE2L2KMT2AGAAPOLB | |
| SCHEMBL1850850 | 0.77 | EGFR (0.53) | EGFRFGFR1KDRKMT2AGAA | |
| SCHEMBL5015931 | 0.76 | KEAP1 (0.68) | KEAP1NFE2L2KMT2AGAAPOLB | |
| SCHEMBL9952564 | 0.75 | OXTR (0.61) | KEAP1NFE2L2KMT2AGAAGLO1 | |
| SCHEMBL5609957 | 0.73 | KEAP1 (0.59) | KEAP1NFE2L2KMT2AGAAPOLB | |
| SCHEMBL30676966 | 0.73 | KEAP1 (0.65) | KEAP1NFE2L2KMT2AALDH1A1HTT | |
| SCHEMBL29118864 | 0.73 | KEAP1 (0.65) | KEAP1NFE2L2KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |