Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850850 | 0.86 | EGFR (0.53) | EGFRFGFR1KDRALDH1A1MEN1 | |
| SCHEMBL4289381 | 0.86 | EGFR (0.70) | EGFRFGFR1KDRCA12CA1 | |
| SCHEMBL9953226 | 0.78 | KEAP1 (0.54) | EGFRFGFR1KDRALDH1A1POLB | |
| SCHEMBL4281632 | 0.77 | ALDH1A1 (0.54) | CA1CA2ALDH1A1MAPTPOLB | |
| SCHEMBL2005010 | 0.75 | CA12 (0.81) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL28439897 | 0.74 | DHX9 (0.51) | EGFRFGFR1KDRCA12CA1 | |
| SCHEMBL15219418 | 0.73 | EGFR (0.59) | EGFRFGFR1KDRCA12CA1 | |
| SCHEMBL25559898 | 0.73 | KIT (0.53) | ALDH1A1MAPTKITKMT2AKDM4E | |
| SCHEMBL24102550 | 0.72 | TDP1 (0.53) | EGFRFGFR1KDRALDH1A1MAPT | |
| SCHEMBL31039619 | 0.72 | ESR1 (0.52) | ALDH1A1HSD17B10MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323987-B1 | N-MYRISTOYL TRANSFERASE INHIBITORS | UNIV DUNDEE (GB) | 2015-06-24 | — | — | EP | disclosed |