SCHEMBL4289544

SCHEMBL4289544

C=Cc1cccc(C(=O)Nc2ccc(NC)c3c2C(=O)c2ccccc2C3=O)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.54
KMT2A Q03164 6/20 0.54
MMP14 P50281 1/20 0.54
CYP1A2 P05177 1/20 0.49
TSHR P16473 1/20 0.49
MAPT P10636 3/20 0.45
TDP1 Q9NUW8 3/20 0.45
MAPK1 P28482 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
RAB9A P51151 2/20 0.45
EGFR P00533 1/20 0.45
PABPC1 P11940 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
CASP3 P42574 2/20 0.44
POLB P06746 2/20 0.42
CCR6 P51684 1/20 0.42
BLM P54132 1/20 0.42
RXFP1 Q9HBX9 1/20 0.42
MAOA P21397 1/20 0.41
LMNA P02545 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4293628 0.87 MAOA (0.53) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL4299603 0.80 MEN1 (0.64) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL6417715 0.79 KMT2A (0.69) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL14380331 0.76 KMT2A (0.67) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL30544874 0.75 MEN1 (0.82) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL6419867 0.75 MEN1 (0.82) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL6421461 0.75 MEN1 (0.60) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL6424210 0.75 MEN1 (0.60) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL4305458 0.75 MEN1 (0.76) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL4291253 0.75 MEN1 (0.57) MEN1KMT2AMMP14CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-104284942-B Stable artificial lens polymerism ultraviolet radiation absorption pigment 兴和株式会社 2016-09-07 CN disclosed
CN-104284942-A Stable polymerizable UV-absorbing colorant for intraocular lens KOWA CO 2015-01-14 CN disclosed
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS MENICON CO., LTD. (JP) 2013-08-08 US disclosed
EP-2581394-A1 IONIC COMPOUND, COMPOSITION, CURED PRODUCT, HYDROGEL, AND OCULAR LENS Menicon Co., Ltd. (JP) 2013-04-17 EP disclosed
EP-1696257-B1 CONTACT LENS MATERIAL MENICON CO LTD (JP) 2012-11-21 EP disclosed
US-20090247662-A1 Contact Lens Material MATSUMOTO MASAHIRO 2009-10-01 US disclosed
EP-1033590-B1 Ocular lens material MENICON CO LTD (JP) 2008-05-07 EP disclosed
US-20070149699-A1 Contact lens material MENICON CO., LTD. (JP) 2007-06-28 US disclosed
EP-1696257-A1 CONTACT LENS MATERIAL MENICON CO., LTD. (JP) 2006-08-30 EP disclosed
US-6329445-B1 Ocular lens material MENICON CO., LTD (JP) 2001-12-11 US disclosed
EP-1033590-A2 Ocular lens material Menicon Co., Ltd. (JP) 2000-09-06 EP disclosed
EP-0947856-A2 Ocular lens material Menicon Co., Ltd. (JP) 1999-10-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS CRYZ, CRYAA, VIL1 MEN1 1583/4885KMT2A 3332/4885MMP14 1405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.