SCHEMBL4293628

SCHEMBL4293628

C=Cc1cccc(C(=O)Nc2cccc3c2C(=O)c2ccccc2C3=O)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.53
MEN1 O00255 5/20 0.51
KMT2A Q03164 5/20 0.51
MMP14 P50281 1/20 0.51
CASP3 P42574 3/20 0.50
CYP1A2 P05177 2/20 0.49
TSHR P16473 1/20 0.49
MAPT P10636 3/20 0.47
RAB9A P51151 3/20 0.47
MAPK1 P28482 2/20 0.47
ALDH1A1 P00352 2/20 0.47
NPC1 O15118 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
HSD17B10 Q99714 1/20 0.45
EGFR P00533 1/20 0.44
PABPC1 P11940 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4654042 0.87 MAOA (0.56) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL4289544 0.87 MEN1 (0.54) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL21436534 0.87 MAOA (0.65) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL4285958 0.83 CASP3 (0.52) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL4622432 0.82 CASP3 (0.69) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL4304874 0.81 MAOA (0.62) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL12960466 0.81 MAOA (0.69) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL30111337 0.79 CASP3 (0.73) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL29607631 0.79 CASP3 (0.73) MAOAMEN1KMT2AMMP14CASP3
SCHEMBL2877019 0.79 CASP3 (0.73) MAOAMEN1KMT2AMMP14CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-104284942-A Stable polymerizable UV-absorbing colorant for intraocular lens KOWA CO 2015-01-14 CN disclosed
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS MENICON CO., LTD. (JP) 2013-08-08 US disclosed
EP-2581394-A1 IONIC COMPOUND, COMPOSITION, CURED PRODUCT, HYDROGEL, AND OCULAR LENS Menicon Co., Ltd. (JP) 2013-04-17 EP disclosed
EP-1696257-B1 CONTACT LENS MATERIAL MENICON CO LTD (JP) 2012-11-21 EP disclosed
US-20090247662-A1 Contact Lens Material MATSUMOTO MASAHIRO 2009-10-01 US disclosed
EP-1033590-B1 Ocular lens material MENICON CO LTD (JP) 2008-05-07 EP disclosed
US-20070149699-A1 Contact lens material MENICON CO., LTD. (JP) 2007-06-28 US disclosed
EP-1696257-A1 CONTACT LENS MATERIAL MENICON CO., LTD. (JP) 2006-08-30 EP disclosed
US-6329445-B1 Ocular lens material MENICON CO., LTD (JP) 2001-12-11 US disclosed
EP-1033590-A2 Ocular lens material Menicon Co., Ltd. (JP) 2000-09-06 EP disclosed
EP-0947856-A2 Ocular lens material Menicon Co., Ltd. (JP) 1999-10-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS CRYZ, CRYAA, VIL1 MAOA 3740/4885MEN1 1583/4885KMT2A 3332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.