Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734007 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11565879 | 0.74 | L3MBTL1 (0.45) | MAPTHTR2AHTR2CHTR2BACHE | |
| SCHEMBL2422880 | 0.73 | ADRA2A (0.33) | ALDH1A1MAPTSMN1; SMN2GAAADRA2B | |
| SCHEMBL22620577 | 0.72 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL11808683 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MAPTSMN1; SMN2DRD2ADRA2B | |
| SCHEMBL12714862 | 0.72 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9572756 | 0.72 | AOC3 (0.47) | ALDH1A1KDM4EHPGDKMT2AAOC3 | |
| SCHEMBL11112463 | 0.71 | CASP1 (0.40) | ALDH1A1MAPTGAAAOC3 | |
| SCHEMBL9207729 | 0.71 | TSHR (0.52) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9008385 | 0.71 | AOC3 (0.49) | ALDH1A1MAPTSMN1; SMN2AOC3CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4601852-A | Process for the preparation of human or the derivatives thereof from pig insulin or the derivatives thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-07-22 | — | — | US | claimed |
| US-8410048-B2 | Method for producing insulin analogs having a dibasic B chain terminus | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2013-04-02 | — | — | US | disclosed |
| US-20090192073-A1 | METHOD FOR PRODUCING INSULIN ANALOGS HAVING A DIBASIC B CHAIN TERMINUS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192073-A1 | METHOD FOR PRODUCING INSULIN ANALOGS HAVING A DIBASIC B CHAIN TERMINUS | IAPP, IDE, INSR | ALDH1A1 3890/4885MAPT 4651/4885SMN1; SMN2 4107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.