SCHEMBL4294561

SCHEMBL4294561

CCc1ccc(C(O)c2ccc(C)nc2OCc2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.42
TSHR P16473 2/20 0.42
HPGD P15428 2/20 0.42
HTT P42858 2/20 0.42
ALDH1A1 P00352 1/20 0.42
MAPK1 P28482 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.41
MAPT P10636 1/20 0.40
DAPK1 P53355 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
GAA P10253 1/20 0.37
CASP3 P42574 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
GBA1 P04062 1/20 0.36
ALOX5 P09917 1/20 0.36
BCHE P06276 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4291107 0.87 CYP1A2 (0.46) LMNATSHRHPGDHTTALDH1A1
SCHEMBL154396 0.82 L3MBTL1 (0.47) LMNATSHRHPGDHTTALDH1A1
SCHEMBL4285312 0.82 CNR2 (0.37) LMNATSHRHPGDHTTALDH1A1
SCHEMBL5377818 0.81 TSHR (0.43) LMNATSHRHPGDHTTALDH1A1
SCHEMBL1539311 0.77 LIPE (0.45) LMNAALDH1A1MAPK1L3MBTL1MAPT
SCHEMBL3223738 0.71 SMN1; SMN2 (0.39) MAPK1L3MBTL1MAPTGAA
SCHEMBL27301730 0.71 L3MBTL1 (0.56) LMNATSHRHPGDHTTALDH1A1
SCHEMBL4810219 0.71 SLC6A9 (0.43) LMNAHPGDHTTALDH1A1MAPK1
SCHEMBL6377672 0.70 MAPT (0.44) LMNATSHRHPGDHTTALDH1A1
SCHEMBL7147661 0.70 LMNA (0.42) LMNATSHRHPGDHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 LMNA 3975/4885TSHR 2115/4885HPGD 2655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.