Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.40 |
| ▸ | FEN1 | P39748 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31232639 | 0.82 | PTGS2 (0.58) | ALDH1A1MAPK1MAPTPTGS2PTGS1 | |
| SCHEMBL13439490 | 0.80 | PTPRC (0.57) | ALDH1A1MAOBMAPTALOX5APFEN1 | |
| SCHEMBL30665733 | 0.80 | PTPRC (0.57) | ALDH1A1MAOBMAPTALOX5APFEN1 | |
| SCHEMBL16850562 | 0.77 | PTPRC (0.58) | MAOBALOX5APFEN1PTPRCPTPN1 | |
| SCHEMBL12489603 | 0.77 | ALDH1A1 (0.83) | ALDH1A1MAPK1MAOBNPC1TP53 | |
| SCHEMBL3569651 | 0.76 | ALDH1A1 (0.65) | ALDH1A1MAPK1MAOBNPC1TP53 | |
| SCHEMBL3564382 | 0.75 | MAPK1 (0.58) | ALDH1A1MAPK1MAOBTP53MAPT | |
| SCHEMBL396633 | 0.75 | FEN1 (0.55) | ALDH1A1MAOBALOX5APFEN1PTGS2 | |
| SCHEMBL9181957 | 0.75 | ESR2 (0.53) | ALDH1A1MAOBNPC1MAPTHPGD | |
| SCHEMBL3750009 | 0.75 | MAOB (0.42) | MAOBTP53ALOX5APFEN1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260035339-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ATRANSEN PHARMA LTD (JP) | 2026-02-05 | — | — | US | disclosed |
| EP-4501906-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | Atransen Pharma Ltd. (JP) | 2025-02-05 | — | — | EP | disclosed |
| CN-118974007-A | Tetrahydronaphthalene derivatives | 阿创森制药股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023190878-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | Ａｔｒａｎｓｅｎ Ｐｈａｒｍａ株式会社 | 2023-10-05 | — | — | WO | disclosed |
| US-20090275581-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2009-11-05 | — | — | US | disclosed |
| US-20090264428-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275581-A1 | RENIN INHIBITORS | REN, ACE, SERPINB1 | ALDH1A1 1084/4885MAPK1 1494/4885MAOB 668/4885 |
| US-20260035339-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | LATS1, LATS2, BCAT1 | ALDH1A1 1267/4885MAPK1 152/4885MAOB 3050/4885 |
| US-20090264428-A1 | Renin Inhibitors | REN, ACE, SERPINB1 | ALDH1A1 1060/4885MAPK1 2221/4885MAOB 1027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.