Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 4/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297600 | 0.92 | KDM5A (0.42) | CA12CA1CA9KDM5APHF8 | |
| SCHEMBL4394110 | 0.89 | DNM1 (0.48) | CA12CA1CA9KDM5APHF8 | |
| SCHEMBL5243912 | 0.88 | CA12 (0.35) | CA12CA1CA9KDM5AHTR1A | |
| SCHEMBL4393301 | 0.88 | CA12 (0.42) | CA12CA1CA9KDM5APHF8 | |
| Iodomethane SCHEMBL8377899 | 0.84 | CA12 (0.42) | CA12CA1CA9KDM5APHF8 | |
| SCHEMBL27566038 | 0.84 | TSHR (0.46) | CA12CA1CA9KDM5APHF8 | |
| SCHEMBL3904839 | 0.84 | TSHR (0.46) | CA12CA1CA9KDM5APHF8 | |
| SCHEMBL896 | 0.84 | TSHR (0.46) | CA12CA1CA9KDM5APHF8 | |
| SCHEMBL7927964 | 0.83 | CA12 (0.39) | CA12CA1CA9KDM5APHF8 | |
| SCHEMBL8053577 | 0.83 | DNM1 (0.48) | CA12CA1CA9KDM5APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499507-B2 | Method for preparing 5-amino-benzoyl-benzofuran derivatives | SANOFI (FR) | 2016-11-22 | — | — | US | claimed |
| US-20150031901-A1 | METHOD FOR PREPARING 5-AMINO-BENZOFURAN DERIVATIVES | SANOFI (FR) | 2015-01-29 | — | — | US | claimed |
| US-8884033-B2 | Process for preparing aminobenzoylbenzofuran derivatives | SANOFI (FR) | 2014-11-11 | — | — | US | claimed |
| US-8748636-B2 | Process for preparing benzofuran derivatives substituted at position 5 | SANOFI (FR) | 2014-06-10 | — | — | US | claimed |
| US-20130165674-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | SANOFI (FR) | 2013-06-27 | — | — | US | claimed |
| US-20130165675-A1 | PROCESS FOR PREPARING AMINOBENZOYLBENZOFURAN DERIVATIVES | SANOFI (FR) | 2013-06-27 | — | — | US | claimed |
| WO-2013079866-A1 | METHOD FOR PREPARING 5-AMINO-BENZOYL-BENZOFURAN DERIVATIVES | SANOFI (FR) | 2013-06-06 | — | — | WO | claimed |
| EP-2595977-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | SANOFI (FR) | 2013-05-29 | — | — | EP | claimed |
| EP-2595976-A1 | PROCESS FOR PREPARING AMINOBENZOYLBENZOFURAN DERIVATIVES | SANOFI (FR) | 2013-05-29 | — | — | EP | claimed |
| WO-2012010788-A1 | PROCESS FOR PREPARING AMINOBENZOYLBENZOFURAN DERIVATIVES | SANOFI (FR) | 2012-01-26 | — | — | WO | claimed |
| WO-2012010802-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | SANOFI (FR) | 2012-01-26 | — | — | WO | claimed |
| US-9499507-B2 | Method for preparing 5-amino-benzoyl-benzofuran derivatives | SANOFI (FR) | 2016-11-22 | — | — | US | disclosed |
| US-20150031901-A1 | METHOD FOR PREPARING 5-AMINO-BENZOFURAN DERIVATIVES | SANOFI (FR) | 2015-01-29 | — | — | US | disclosed |
| US-8884033-B2 | Process for preparing aminobenzoylbenzofuran derivatives | SANOFI (FR) | 2014-11-11 | — | — | US | disclosed |
| US-8748636-B2 | Process for preparing benzofuran derivatives substituted at position 5 | SANOFI (FR) | 2014-06-10 | — | — | US | disclosed |
| EP-0818512-A1 | Quinoline derivative and use of same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1998-01-14 | — | — | EP | disclosed |
| US-4562211-A | ANTIDEPRESSANTS | MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) | 1985-12-31 | — | — | US | disclosed |
| US-4091114-A | ANTIDEPRESSANTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1978-05-23 | — | — | US | disclosed |
| US-4060641-A | ANTIDEPRESSANT | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) | 1977-11-29 | — | — | US | disclosed |
| US-4024282-A | Pharmaceutically active 2-(3-alkylaminopropoxy)diphenylmethanes | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) | 1977-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165675-A1 | PROCESS FOR PREPARING AMINOBENZOYLBENZOFURAN DERIVATIVES | ALKBH5, ALKBH1, PRMT5 | CA12 3136/4885CA1 4233/4885CA9 2788/4885 |
| US-20130165674-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | DHPS, SDHA, CYP2F1 | CA12 3351/4885CA1 3298/4885CA9 3448/4885 |
| US-20150031901-A1 | METHOD FOR PREPARING 5-AMINO-BENZOFURAN DERIVATIVES | ALKBH5, CYP3A5, ALKBH1 | CA12 4767/4885CA1 4817/4885CA9 4065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.