SCHEMBL4301345

SCHEMBL4301345

C=Cc1ccccc1C(=O)Nc1cccc2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.56
CASP3 P42574 2/20 0.48
ALDH1A1 P00352 3/20 0.47
POLB P06746 3/20 0.47
MAPT P10636 2/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
GAA P10253 1/20 0.47
DNMT1 P26358 1/20 0.47
RAD52 P43351 1/20 0.47
SMARCA2 P51531 1/20 0.47
CYP1A2 P05177 1/20 0.47
HSD17B10 Q99714 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
EGFR P00533 1/20 0.47
PABPC1 P11940 1/20 0.47
MAPK1 P28482 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20271919 0.86 MAOA (0.69) MAOACASP3ALDH1A1POLBMAPT
SCHEMBL4291092 0.80 MAOA (0.65) MAOACASP3ALDH1A1POLBMAPT
SCHEMBL10870706 0.80 MAOA (0.60) MAOACASP3ALDH1A1POLBMAPT
SCHEMBL11193262 0.80 CHRNB2 (0.62) MAOACASP3ALDH1A1MAPTCYP1A2
SCHEMBL4654042 0.79 MAOA (0.56) MAOACASP3ALDH1A1POLBMAPT
SCHEMBL1804470 0.77 MAPT (0.54) MAOAALDH1A1POLBMAPTMEN1
SCHEMBL5186376 0.77 MAOA (0.65) MAOAALDH1A1POLBMAPTMEN1
SCHEMBL11420387 0.77 MAOA (0.61) MAOACASP3ALDH1A1POLBMAPT
SCHEMBL12960466 0.77 MAOA (0.69) MAOACASP3ALDH1A1POLBMAPT
SCHEMBL4293628 0.77 MAOA (0.53) MAOACASP3ALDH1A1POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-104284942-B Stable artificial lens polymerism ultraviolet radiation absorption pigment 兴和株式会社 2016-09-07 CN disclosed
CN-104284942-A Stable polymerizable UV-absorbing colorant for intraocular lens KOWA CO 2015-01-14 CN disclosed
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS MENICON CO., LTD. (JP) 2013-08-08 US disclosed
EP-2581394-A1 IONIC COMPOUND, COMPOSITION, CURED PRODUCT, HYDROGEL, AND OCULAR LENS Menicon Co., Ltd. (JP) 2013-04-17 EP disclosed
EP-1696257-B1 CONTACT LENS MATERIAL MENICON CO LTD (JP) 2012-11-21 EP disclosed
US-20090247662-A1 Contact Lens Material MATSUMOTO MASAHIRO 2009-10-01 US disclosed
US-20070149699-A1 Contact lens material MENICON CO., LTD. (JP) 2007-06-28 US disclosed
EP-1696257-A1 CONTACT LENS MATERIAL MENICON CO., LTD. (JP) 2006-08-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS CRYZ, CRYAA, VIL1 MAOA 3740/4885CASP3 1443/4885ALDH1A1 2196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.