Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | TK1 | P04183 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306412 | 0.86 | KMT2A (0.42) | KMT2ANPSR1POLBKDM4EMAPT | |
| SCHEMBL4301394 | 0.86 | KMT2A (0.46) | KMT2ANPSR1POLBKDM4EMEN1 | |
| SCHEMBL4302800 | 0.84 | CDYL2 (0.49) | KMT2APOLBKDM4EMAPTMAOB | |
| SCHEMBL4308531 | 0.84 | LMNA (0.43) | KMT2APOLBKDM4EMAPTMEN1 | |
| SCHEMBL4305907 | 0.82 | LMNA (0.38) | KDM4EMAPTALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL4311981 | 0.77 | LMNA (0.44) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL4304477 | 0.75 | TP53BP1 (0.38) | KMT2ANPSR1KDM4EMAPTALDH1A1 | |
| SCHEMBL20139218 | 0.74 | ALDH1A1 (0.38) | POLBKDM4EMAPTALDH1A1 | |
| SCHEMBL4306435 | 0.73 | CYP1A2 (0.41) | KMT2APOLBKDM4EMAPTMEN1 | |
| SCHEMBL16320824 | 0.73 | ALDH1A1 (0.42) | KDM4EMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |