Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | FABP4 | P15090 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949712 | 0.91 | HTR6 (0.84) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL10345778 | 0.89 | MEN1 (1.00) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL29559974 | 0.89 | MEN1 (1.00) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL946548 | 0.87 | HTR6 (0.78) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL31159555 | 0.86 | HTR6 (0.76) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL949160 | 0.86 | HTR6 (0.76) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL945665 | 0.86 | HTR6 (0.76) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL5915283 | 0.86 | HTR6 (0.76) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL31159358 | 0.85 | HTR6 (0.74) | HTR6POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL31159375 | 0.85 | HDAC1 (0.77) | HTR6POLBL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155674-B1 | AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LTD (IN) | 2011-06-22 | — | — | EP | claimed |
| CN-115677722-A | Compounds targeting p53 mutants | 北京加科思新药研发有限公司 | 2023-02-03 | — | — | CN | disclosed |
| EP-3233797-B1 | MAP4K4 (HGK) INHIBITORS | Sri int inc (US) | 2019-05-08 | — | — | EP | disclosed |
| US-10000451-B2 | MAP4K4 (HGK) inhibitors | SRI INTERNATIONAL (US) | 2018-06-19 | — | — | US | disclosed |
| US-20170320824-A1 | MAP4K4 (HGK) Inhibitors | SRI INTERNATIONAL (US) | 2017-11-09 | — | — | US | disclosed |
| EP-3233797-A1 | MAP4K4 (HGK) Inhibitors | SRI International Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016114816-A1 | MAP4K4 (HGK) Inhibitors | SRI INTERNATIONAL (US) | 2016-07-21 | — | — | WO | disclosed |
| CN-105732464-A | Method for producing indole compound in large scale | 杏国新药股份有限公司 | 2016-07-06 | — | — | CN | disclosed |
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-01-26 | — | — | US | disclosed |
| WO-2008136017-A1 | AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-11-13 | — | — | WO | disclosed |
| US-7307099-B2 | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-12-11 | — | — | US | disclosed |
| US-7307099-B2 | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-12-11 | — | — | US | disclosed |
| US-7307099-B2 | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-12-11 | — | — | US | disclosed |
| US-20060100265-A1 | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-05-11 | — | — | US | disclosed |
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | BAXTER ONCOLOGY GMBH | 2003-08-21 | — | — | US | disclosed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | disclosed |
| US-5079363-A | From an alkoxypyridine and an indole derivative, antitumor and antileukemia agents | SANOFI (FR) | 1992-01-07 | — | — | US | disclosed |
| EP-0155214-B1 | 2-SULFAMOYL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4840963-A | FOR GLAUCOMA | MERCK & CO., INC. (US) | 1989-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100265-A1 | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents | TXNRD1, TXNRD3, TXNRD2 | HTR6 1460/4885POLB 1698/4885L3MBTL1 1346/4885 |
| US-20120022121-A1 | INDOLES, DERIVATIVES AND ANALOGS THEREOF AND USES THEREFOR | TUBB, TUBB3, TUBB1 | HTR6 592/4885POLB 1458/4885L3MBTL1 1167/4885 |
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | HTR6 563/4885POLB 3573/4885L3MBTL1 3305/4885 |
| US-20170320824-A1 | MAP4K4 (HGK) Inhibitors | MAP4K4, MAP4K2, MAP4K3 | HTR6 4239/4885POLB 2808/4885L3MBTL1 2987/4885 |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | HTR6 563/4885POLB 3573/4885L3MBTL1 3305/4885 |
| US-10000451-B2 | MAP4K4 (HGK) inhibitors | MAP4K4, MAP4K2, MAP4K3 | HTR6 4239/4885POLB 2808/4885L3MBTL1 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.