Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4307363 | 0.97 | HDAC3 (0.57) | HDAC3HDAC1HDAC2THRATHRB | |
| SCHEMBL26355067 | 0.91 | MAOA (0.60) | THRATHRBMAOAMAOBSMPD1 | |
| SCHEMBL19549621 | 0.91 | MAOA (0.60) | THRATHRBMAOAMAOBSMPD1 | |
| SCHEMBL7288692 | 0.91 | PLA2G2A (0.54) | HDAC3HDAC1HDAC2PLA2G2ATDP1 | |
| SCHEMBL16482859 | 0.89 | MAOA (0.54) | HDAC3HDAC1HDAC2THRATHRB | |
| SCHEMBL9525503 | 0.87 | LMNA (0.54) | HDAC3HDAC1HDAC2THRATHRB | |
| SCHEMBL2454085 | 0.87 | PPARG (0.56) | HDAC3HDAC1HDAC2THRATHRB | |
| SCHEMBL27009292 | 0.84 | TDP1 (0.64) | HDAC3HDAC1HDAC2TDP1MTNR1A | |
| SCHEMBL4057376 | 0.84 | KDM4E (0.50) | TDP1KDM4EALDH1A1HSP90AA1MAPT | |
| SCHEMBL4304889 | 0.83 | PPARG (0.55) | HDAC3HDAC1HDAC2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069430-A1 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROPHARMA, S.A. (ES) | 2009-03-12 | — | — | US | disclosed |
| US-20090069430-A1 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROPHARMA, S.A. (ES) | 2009-03-12 | — | — | US | disclosed |
| US-20090069430-A1 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROPHARMA, S.A. (ES) | 2009-03-12 | — | — | US | disclosed |
| EP-1976823-A1 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Neuropharma, S.A. (ES) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007068754-A1 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROPHARMA, S.A. (ES) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007068754-A1 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROPHARMA, S.A. (ES) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069430-A1 | DIBENZENE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | CACNA1B, CACNB1, CACNA1C | HDAC3 4294/4885HDAC1 3192/4885HDAC2 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.