Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847701 | 0.87 | CA2 (0.59) | CA2KMT2AGPR34ADAMTS5MMP2 | |
| SCHEMBL12678088 | 0.85 | MME (0.59) | CA2ALDH1A1CA1MMEFPR2 | |
| SCHEMBL19328341 | 0.84 | FPR2 (0.56) | CA2CA1MMEFPR2 | |
| SCHEMBL3451686 | 0.82 | FPR2 (0.49) | KMT2AGPR34PYGLFPR2 | |
| SCHEMBL3451680 | 0.82 | FPR2 (0.49) | KMT2AGPR34PYGLFPR2 | |
| SCHEMBL5994613 | 0.81 | LMNA (0.63) | CA2KMT2AGPR34ADAMTS5MMP2 | |
| SCHEMBL7773682 | 0.81 | LMNA (0.63) | CA2KMT2AGPR34ADAMTS5MMP2 | |
| SCHEMBL7773675 | 0.81 | LMNA (0.63) | CA2KMT2AGPR34ADAMTS5MMP2 | |
| SCHEMBL29511612 | 0.81 | KMT2A (0.54) | CA2KMT2AGPR34PRSS1PRSS2 | |
| SCHEMBL27699871 | 0.80 | CA2 (0.54) | CA2KMT2AGPR34ADAMTS5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120316208-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-12-13 | — | — | US | disclosed |
| US-20120316208-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-12-13 | — | — | US | disclosed |
| US-8273778-B2 | Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-09-25 | — | — | US | disclosed |
| US-8273778-B2 | Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-09-25 | — | — | US | disclosed |
| US-20100056586-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-03-04 | — | — | US | disclosed |
| US-20100056586-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-03-04 | — | — | US | disclosed |
| WO-2009132310-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009132310-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056586-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | UGDH, UGGT1, UMPS | CA2 4600/4885KMT2A 3592/4885GPR34 3866/4885 |
| US-20120316208-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | UGDH, UGGT1, UMPS | CA2 4600/4885KMT2A 3592/4885GPR34 3866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.