Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312281 | 1.00 | GPR119 (0.54) | GPR119USP30STSPIK3CDMEN1 | |
| SCHEMBL21436867 | 0.96 | GPR119 (0.57) | GPR119USP30STSPIK3CDMEN1 | |
| SCHEMBL2793124 | 0.89 | GPR119 (0.65) | GPR119STSMEN1KMT2ACHEK2 | |
| SCHEMBL15376614 | 0.85 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL699609 | 0.85 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL699608 | 0.85 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL6189661 | 0.85 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL20179924 | 0.85 | GPR119 (0.58) | GPR119USP30PIK3CDKMT2ACHEK2 | |
| SCHEMBL31142651 | 0.85 | ALDH1A1 (0.60) | GPR119USP30STSPIK3CDALDH1A1 | |
| SCHEMBL1990925 | 0.85 | NPC1 (0.55) | GPR119USP30PIK3CDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-09-17 | — | — | US | disclosed |
| US-7576102-B2 | Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2009-08-18 | — | — | US | disclosed |
| EP-1963261-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007073407-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-06-28 | — | — | WO | disclosed |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTC4S, LTB4R | GPR119 1988/4885USP30 2744/4885STS 545/4885 |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTC4S, LTB4R | GPR119 1988/4885USP30 2744/4885STS 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.